Nucleic acid constructs containing stable stem and loop structur

Details Nucleic acid constructs containing stable stem and loop structur Nucleic acid constructs containing stable stem and loop structur

1992-04-10

1993-05-04

Low, Christopher S. F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

4352523, 43525233, 435254, 4351721, 4353201, 4351723, 4352402, 800 2, 536 231, 536 241, 536 235, 536 237, 514 44, 935 2, 935 3, 935 6, 935 33, 935 36, 935 55, 935 62, 935 66, C12N 510, C12N 111, C12N 1509

Patent

active

052081494

ABSTRACT:
Gene expression in a cell can be regulated or inhibited by incorporating into or associating with the genetic material of the cell a non-native nucleic acid sequence which is transcribed to produce an mRNA which is complementary to and capable of binding to the mRNA produced by the genetic material of said cell.

REFERENCES:
patent: 4469893 (1984-09-01), T'so et al.
patent: 4503151 (1985-03-01), Paddock et al.
patent: 4511713 (1985-04-01), Miller et al.
patent: 4740463 (1988-04-01), Weinberg et al.
patent: 4801540 (1989-01-01), Hiatt et al.
patent: 4912040 (1990-03-01), Kaufman et al.
patent: 5023243 (1991-06-01), Tullis et al.
Tomizawa et al. "Plasmid ColEl incompatibility determined by interaction of RNA I with primer transcript" Proc. Natl. Acad. Sci. USA 78:6096-6100 (1981).
Stryer "Biosynthesis of Nucleotides" in Biochemistry, W. H. Freeman & Co., S. F. pp. 528-531 (1975).
Zimmer et al. "Genome Distribution of Adenovirus Total and Self- Complementary Nuclear RNA at Early Times" Virology 111:301-311 (1981).
Izant et al. "Constitutive and Conditional Suppression of Exogenous and Endogenous Genes by Anti-Sense RNA" Science 229:345-52 (1985).
Nordstrom "Antisense RNA" Trends in Biochem. Sci. 10 (6):232 (1985).
Izant et al. "Inhibition of Thymidine Kinase Gene Expression by Anti-Sense RNA: A Molecular Approach to Genetic Analysis" Cell 36:1007-15 (1984).
Stephenson et al. "Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide" Proc. Natl. Acad. Sci. USA 75:285-288 (1978).
Zamecnik et al. "Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide" Proc. Natl. Acad. Sci. USA 75:280-284 (1978).
Maniatis et al. Molecular Cloning, A Laboratory Manual, Cold Spring Harbor Laboratory, pp. 211-246 and 405-410 (1982).
Fraley et al. "Expression of bacterial genes in plant cells" Proc. Natl. Acad. Sci. USA 89:4803-4807 (1983).
Melton "Injected anti-sense RNAs specifically block messenger RNA translation in vivo" Proc. Natl. Acad. Sci. USA 82:144-148 (1985).
Kim & Wold "Stable reduction of thymidine kinase activity in cells expressing high levels of anti-sense RNA" Cell 42:129-138 (1985).
Crowley et al. "Phenocopy of Discoidin I-Minus Mutants by Antisense Transformation in Dictyostelium" Cell 43:633-641 (1985).
Hirashima et al. "Engineering of the mRNA-interfering complementary RNA immune system against viral infection" Proc. Natl. Acad. Sci. USA 83:7726-7730 (1986).
Ecker et al. "Inhibition of gene expression in plant cells by expression of antisense RNA" Proc. Natl. Acad. Sci. USA 83:5372-5376 (1986).
Rosenberg et al. "Production of phenocopies by Kruppel antisense RNA injection into Drosophila embryos" Nature 313:703-706 (1985).
McGarry et al. "Inhibition of heat shock protein synthesis by heat-inducible antisense RNA" Proc. Natl. Acad. Sci. USA 83:399-403 (1986).
Holt et al. "Inducible production of c- fos antisense RNA inhibits 3T3 cell proliferation" Proc. Natl. Acad. Sci. USA 83:4794-4798 (1986).
Ellison et al. "Thermal Regulation of .beta.-Galactosidase Synthesis Using Anti-sense RNA Directed against the Coding Portion of the mRNA" J. Biol. Chem. 260:9085-9087 (1985).
Stougaard et al. "Vertical Dye-Buoyant Density Gradients for Rapid Analysis and Preparation of Plasmid DNA" Anal. Biochem. 118:191-193 (1981).
Stougaard et al. "RNAs involved in copy-number control and incompatibility of plasmid R1" Proc. Natl. Acad. Sci. USA 78:6008-6012 (1981).
Zipser, D. "Polarity and Translational Punctuation" in Beckwith, J. R. and Zipser, D. (eds) The Lactose Operon, Cold Spring Harbor Lab Press, N.Y., pp. 221-232 (1970).
Cesareni et al. "Control of ColE1 DNA replication: The rop gene product negatively affects transcription from the replication primer promoter" Proc. Natl. Acad. Sci. USA 79:6313-17 (1982).
Tomizawa et al. "Control of ColE1 Plasmid Replication: Enhancement of Binding of RNA I to the Primer Transcript by the Rom Protein" Cell 38:871-878 (1984).
Cesareni et al. "Control of pMB1 replication: inhibition of primer formation by Rop requires RNA1" EMBO J. 3:1365-69 (1984).
Schell et al. "Gene Vectors for Higher Plants", in Genetic Engineering: Applications to Agriculture, pp. 200-202, Beltsville Symposia in Agricultural Research (L. D. Owens ed.) (1983).
Lewin Genes, pp. 165-166, pp. 174-194, pp. 310-311 (First Ed.) (1983).
Lewin Genes, pp. 50-52, pp. 553-560 (First Ed.) (1983).
Green et al. "The role of antisense RNA in gene regulation" Ann. Rev. Biochem. 55:569-97 (1986).
Mizuno et al. "A unique mechanism regulating gene expression: Translational inhibition by a complementary RNA transcript (mic RNA)" Proc. Natl. Acad. Sci. USA 81:1966-1970 (1984).
Coleman et al. "The Use of RNAs Complementary to Specific mRNAs to Regulate the Expression of Individual Bacterial Genes" Cell 37:429-436 (1984).
Boyer et al. Genetic Engineering Elsevier/North-Holland Biomedical Press pp. 25, 26 and 163 (1978).
Mizuno et al. "Regulation of Gene Expression by a Small RNA Transcript (micRNA) in Escherichia coli K-12" Proc. Jap. Acad. 59(B): 335-338 (1983).
La Porte "Antisense RNA: a new mechanism for the control of gene expression" Trends in Biochem. Sci. 9:463 (1984).
Wong, et al. "Electric Field Mediated Gene Transfer" Biochem. Biophys. Res. Comm. 107: 584-587 (1982).
Chilton "A vector for Introducing New Genes Into Plants" Scientific American 248: 50-59 (1983).
Weinstein, et al. "Cellular DNA Sequences Involved in Chemical Carcinogenesis" in Genes and Proteins in Oncogenes, Academic Press, N.Y. pp. 253-265 (1983).
Naora and Deacon "Nucleotide sequence complementarity between Adenovirus 2-coded RNA and host cell premessenger RNA: A possible regulatory mechanism of cellular RNA splicing by VA RNA" Biol. Abs. 73:3743, abstract No. 36372 (1982).
Daniels and Alberty Physical Chemistry, John Wiley & Sons, 4th ed. pp. 156, 170 (1975).
Salser "Globin mRNA Sequences: Analysis of Base Pairing and Evolutionary Implications" Cold Spring Harbor Symp. Quant. Biol. 12:985-1002 (1987).
Fresco "A New spectroscopic Approach to the Determination of Helical Secondary Structure in Ribonucleic Acids" Cold Spring Harbor Symp. Quant. Biol. 28:83-90 (1963).
Fresco, et al. "Some Molecular Details of the Secondary Structure of Ribonucleic Acid" Nature 188:98-101 (1960).
Paterson et al. "Structural gene identification and mapping by DNA:mRNA hybrid-arrested cell-free translation" Chemical Abstract 87:196,773t (1977).
Paterson et al. "Structural gene identification and mapping by DNA:mRNA hybrid-arrested cell-free translation" Proc. Natl. Acad. Sci. USA 74:4370-4374 (1977).
Hastie et al. "Analysis of mRNA populations by cDNA-mRNA hybrid-mediated inhibi
This invention was made with Government support under Grant no. R01-GM-19043 awarded by National Science Foundation. The Government has certain rights in the invention.

Affiliated with

Also associated with

Rating

Nucleic acid constructs containing stable stem and loop structur does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acid constructs containing stable stem and loop structur, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid constructs containing stable stem and loop structur will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1974734