Nucleic acid construct encoding a processing component...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector

Reexamination Certificate

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C424S189100, C530S324000

Reexamination Certificate

active

07341723

ABSTRACT:
A method for enhancing an immune response to a nucleic acid vaccine comprising administering to an animal a nucleic acid construct encoding a fusion protein comprising a processing component and an antigenic polypeptide of interest wherein said processing component provides heterogeneous processing of the antigenic polypeptide when the nucleic acid construct is expressed in a host cell and a resulting enhancement of the immune response. The processing component is derived from an N-terminal portion of PORF2 of Hepatitis E virus.

REFERENCES:
He J. et al “DNA inoculation with a plasmid vector carrying the hepatitis E virus structural protein gene induces immune response in mice” Vaccine vol. 15 (1997), No. 4, pp. 357-362.

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