Nucleic acid construct encoding a nuclear transport peptide oper

Details Nucleic acid construct encoding a nuclear transport peptide oper Nucleic acid construct encoding a nuclear transport peptide oper

1993-11-29

1996-12-31

Stone, Jacqueline M.

Chemistry: molecular biology and microbiology

Vector, per se

536 231, 536 234, 536 237, 536 241, C12N 1509, C12N 1563, C07H 2102, C07H 2104

Patent

active

055893929

ABSTRACT:
A system for regulating expression of eukaryotic genes in cells is described. The system contains two recombinant DNA molecules, a first molecule that encodes a nucleus-targeted inducible repressor polypeptide, and a second molecule that encodes an operator-regulated reporter polypeptide. Transgenic animals containing the system, and methods for using the system are also described.

REFERENCES:
Lyons et al., Mol. and Cell. Biol., 7:2451-2456 (1987)--Pentapeptide Nuclear Localization Signal in Adenovirus Ela.
Scangas et al (1987) Adv. Genet. 24, 285-322.
Hu et al (1987) Cell 48, 555-566.
Dunn et al (1988) Gene 68, 259-266.
Langford et al (1986) Cell 46, 575-582.
Miller et al (1980) The Operon, 134.
Hu et al (1987) Cell 48, 555-566.
Sadowski et al (1988) Nature, 335, 563-54.
Scangos et al (1987) Adv in Genet. 27, 285-322.

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