Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1973-10-30
1977-05-17
Brown, Johnnie R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
195 28N, 2601125R, 424 85, 536 22, 536 23, 536 24, 536 25, 536 28, 536 29, A61K 31665, A61K 31715, C07H 1910, C07H 2100
Patent
active
040242226
ABSTRACT:
The present invention relates to the induction of interferon production in the cells of living organisms, including human beings. According to the invention, nucleic acid complexes, such as the polyriboinosinate and polycytidylate complex (rI.sub.n.rC.sub.n), are modified to yield unpaired bases (uracil or guanine) along the polycytidylate strand which render the complexes more readily hydrolyzable by nucleases present in living cells. The modified complexes retain their ability to stimulate interferon release by the cells but are rendered more vulnerable to destruction within the cells, the modified complexes being significantly less toxic than the original complexes. In addition, polyinosinate strand now has been prepared to contain 5-16% 2'-O-methyl inosinate residues, designated as (rI.sub.5-20,2'-MeI).sub.n. The new complex (rI.sub.5-20,2'-MeI).sub.n.rC.sub.n, exhibits 100-fold more activity than rI.sub.n.rC.sub.n as an interferon inducer in human cells.
REFERENCES:
patent: 3775398 (1973-11-01), Harnden
patent: 3803116 (1974-04-01), Sekiguchi et al.
patent: 3843629 (1974-10-01), Scheit et al.
patent: 3845033 (1974-10-01), Harnden
Carter William A.
T'so Paul O. P.
Brown Johnnie R.
Finch Walter G.
The Johns Hopkins University
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