Nucleic acid coding for the human angiotensin converting enzyme

Details Nucleic acid coding for the human angiotensin converting enzyme Nucleic acid coding for the human angiotensin converting enzyme

1994-08-12

1996-01-02

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 691, 4353201, 4352523, 536 232, C12N 948, C12N 1563, C12N 121, C12N 1557, C12P 2102

Patent

active

054807930

ABSTRACT:
The invention relates to the cloning and sequencing of the nucleic acid coding for the human ACE as well as the determination of the peptide chain corresponding to the ACE and of active peptide fragments which derive from it.
Another subject of the invention is the utilization of the above-mentioned polypeptides for the implementation of in vitro diagnostic methods for hypertension and for the design of new inhibitors of the ACE.
The invention also relates to the utilization of the nucleotide probes of the invention for the in vitro screening of the polymorphisms of the gene coding for the ACE.

REFERENCES:
patent: 4358535 (1982-11-01), Falkow et al.
K. E. Bernstein et al, "The Isolation of Angiotensin-converting Enzyme cDNA" The Journal of Biological Chemistry, 263, n. 23, Aug. 15, 1988, pp. 11021-11024.
H. G. Bull et al, "Purification of Angiotensin-converting Enzyme from Rabbit Lung and Human Plasma by Affinity Chromatography", The Journal of Biological Chemistry, 260, n. 5, Mar. 10, 1985, pp. 2963-1972.
T. Kreofsky et al, "Purification of Human Lung Angiotensin Converting Enzyme (ACE) and Production of Anti-Catalytic Monoclonal Antibodies MoAb", Federation Proceedings (US), 45, (6) (1986).
R. K. A. Allen et al, "Monoclonal Antibodies to Human Pulmonary Angiotensin-Converting Enzyme", Australian and new Zealand Journal of Medicine, Suppl. 2, 18, (3): 547 (1988).
Iwata et al, JP-A-61 186 399 (Fuji Pharmaceutical), Chemical Abstracts, 106, p. 470, No. 16946f (1987).
Danilov et al, "Monoclonal Antibody to Human Lung Angiotensin-Converting Enzyme", Biotechnol. Appl. Biochem. 9: 319-322 (1987), & Chemical Abstracts, 108, p. 266, No. 18303j (1988).
Hiroshi et al, "Pharmacological Comparison of Captopril and MK-422 by a New Method for Measuring Activity of Angiotension Converting Enzyme (ACE)", Chemical Abstracts, vol. 104, 1986, voir p. 7, resume No. 179632y & Jpn. Circ. J. 49: 1175-1179 (1985).
Deluca-Flaherty et al, "Hybridization and Partial cDNA Sequence Analyses of Bovine Lung Angiotensin I-Converting Enzyme", Int. J. Pept. Protein Res. 29: 678-684 (1987) (cited on p. 2 of this application), Chemical Abstrcts, 107, p. 169, No. 148356u (1987).
Bernstein et al, "Multiple Forms of Angiotensin-Converting Enzyme ACE Complementary DNA", Biological Abstracts/RMM, accession No. 36105199, & Laboratory Investigation *US) 60(1): 9A (1989).

Affiliated with

Also associated with

Rating

Nucleic acid coding for the human angiotensin converting enzyme does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acid coding for the human angiotensin converting enzyme , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid coding for the human angiotensin converting enzyme will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-234515