Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-08-04
1999-12-21
Degen, Nancy
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 691, 435 911, 435183, 536 231, 536 2431, 536 2432, C12Q 168, C12P 2100, C12N 900, C07H 2104
Patent
active
06004750&
ABSTRACT:
The invention relates to nucleic acid clamps and methods for using nucleic acid clamps, for example, to inhibit gene expression or cleavage, or to specifically cleave a target nucleic acid. Nucleic acid clamps are molecular devices which can bind nucleic acids with affinity and specificity and have a recognition sequence as small as seven bases. Nucleic acid clamps can be used to modify the effective recognition sequence of restriction endonucleases, reducing the frequency and enhancing the length of the recognition sequence, but without diminishing specificity. The invention also relates to methods for the use of nucleic acid clamps for the treatment of disorders involving abnormal gene expression.
REFERENCES:
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Demidov Vadim V.
Frank-Kamenetskii Maxim D.
Veselkov Alexei G.
Degen Nancy
Sandals William
The Trustees of Boston University
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