Chemistry: molecular biology and microbiology – Vector – per se
Patent
1998-09-22
2000-10-03
Schwartzman, Robert A.
Chemistry: molecular biology and microbiology
Vector, per se
435 6, 435 911, 435 9131, 435325, 435375, 536 231, 536 232, C12Q 168, C12P 1934, C12N 1500, C12N 500
Patent
active
06127173&
ABSTRACT:
Nucleic acid molecules with new motifs having catalytic activity, methods of synthesis, and use thereof are also described.
REFERENCES:
patent: 5298612 (1994-03-01), Jennings et al.
patent: 5334711 (1994-08-01), Sproat et al.
patent: 5624803 (1997-04-01), Noonberg et al.
patent: 5688670 (1997-11-01), Szostak et al.
patent: 5807718 (1998-09-01), Joyce et al.
patent: 5861501 (1999-01-01), Benseler et al.
Bartel and Szostak, "Isolation of New Ribozymes From a Large Pool of Random Sequences," Science 261:1411-1418 (1993).
Beaudry and Joyce, "Directed Evolution of an RNA Enzyme, " Science 257:635-641 (1992).
Beaudry and McSwiggen, "Quantitation of Ribozyme Target Abundance by QCPCR," Methods of Molecular Biology 74(34):325-339.
Been et al., "Secondary Structure of the Self-Cleaving RNA of Hepatitis Delta Virsus: Applications to Catalytic RNA Design, " Biochemistry 31:11843-11852 (1992).
Beigalman et al., "Chemical Modification of Hammerhead Ribozymes, " J. Biol. Chem. 270:25702-25708 (1995).
Beigalman et al., "Synthesis of 1-Deoxy-D-Ribofuranose Phosphoramidite & The Incorporation of Abasic Nucleotides in the Stem-Loop II of a Hammerhead Ribozyme," Bioorganic & Medicinal Chemistry Letters 4:1715-1720 (1994).
Benseler et al., "Hammerhead-like Molecules Containing Non-Nucleoside Linkers Are Active RNA Catalysts," J. Am. Chem. Soc. 115:8483-8484 (1993).
Breaker and Joyce, "Inventing and improving ribozyme function: rational design versus iterative selection methods," TIBTECH 12:268-275 (1994).
Andrea D. Branch, A good antisense molecule is hard to find, TIBS, 47-48, Feb. 1998.
Trisha Gura, antisense Has Growing Pains, Science, pp. 575-577, Oct. 1995.
Stanley Crooke, Antisense '97: A roundtable on the state of the industry, Nature Biotechnology, p. 522, Jun. 1997.
Stanley Crooke, Antisense Research and Applications, Chapter 1, Basic Principles of Antisense Therapeutics, Springer-Verlag Press, Berlin, Heidelberg, New York, P. 3, Jul. 1998.
Breaker, "Are engineered proteins getting competition from RNA?" Current Opinion in Biotechnology 7:442-448 (1996).
Burgin et al., "Chemically modified hammerhead ribozymes with improved catalytic rates," Biochemistry 35:14090-14097 (1996).
Cech, "Ribozyme Engineering, " Current Opinion in Structural Biology 2:605-609 (1992).
Cech, "Ribozymes and Their Medical Implications," JAMA 260:3030-3034 (1988).
Chen et al., "Multitarget-Ribozyme Directed to Cleave at up to Nine Highly Conserved HIV-1 env RNA Regions Inhibits HIV-1 Isolates, " Nucleic Acids Research 20:4581-4589 (1992).
Chowrira et al., "In Vitro and in Vivo Comparison of Hammerhead, Hairpin, and Hepatitis Delta Virus Self-Processing Ribozyme Cassettes, " J.Biol. Chem. 269:25856-25864 (1994).
Christoffersen and Marr, "Ribozymes as Human Therapeutic Agents, " J. Med. Chem. 38:2023-2037 (1995).
Cload and Schepartz, "Polyether Tethered Oligonucleotide Probes, " J. Am. Chem. Soc. 113:6324-6326 (1991).
Couture and Stinchcomb, "Anti-gene therapy: the use of ribozymes to inhibit gene function," Trends In Genetics 12:510-515 (1996).
Dropulic et al., "Functional Characterization of a U5 Ribozyme: Intracellular Suppression of Human Immunodefiency Virus Type I Expression ," Journal of Virology 66:1432-1441 (1992).
Durand et al., "Circular Dichroism Studies of an Oligodeoxyribonucleotide Containing a Hairpin Loop Made of a Hexaethylene Glycol Chain: Conformation and Stability," Nucleic Acids Research 18:6353-6359 (1990).
Elroy-Stein and Moss, "Cytoplasmic Expression System Based on Constitutive Synthesis of Bacteriophage T7 RNA Polymerase in Mammalian Cells,"Proc. Natl. Acad. Sci. USA 87:6743-6747 (1990).
Ferentz and Verdine, "Disulfied Cross-Linked Oligonucleotides," J. Am. Chem. Soc. 113:4000-4002 (1991).
Forster and Symons, "Self-Cleavage of Plus and Minus RNAs of a Virusoid and a Structural for the Active Sites," Cell 49:211-220 (1987).
Frank et al., "In vitro selection of Rnase P RNA reveals optimized catalytic activity in a highly conserved structural domain, " RNA 2:1179-1188(1996).
Gao and Huang, "Cytoplasmic Expression of a Reporter Gene by Co-Delivery of T7 RNA Polymerase and T7 Promoter Sequence with Cationic Liposomes," Nucleic Acids Research 21:2867-2872 (1993).
Gold et al., Diversity of Oligonucleotide Functions, Annu. Rev. Biochem. 64:763-797 (1995).
Good et al., "Expression of small, therapuetic RNAs in human nuclei," Gene Therapy 4:45-54 (1997).
Guo and Collins, "Efficent Trans-cleavage of a stem-loop RNA substrate by a ribozyme derived from Neurospora VS RNA," EMBO J. 14:368-376 (1995).
Hendry et al., "Using linkers to investigate the spatial separation of the conserved nucleotides A.sub.9 and G.sub.12 in the Hammerhead Ribozyme," Biochemica et Biophysica Acta 1219:405-412 (1994).
Hertel et al., "A Kinetic Thermodynamic Framework for the Hammerhead Ribozyme Reaction," Biochemistry 33:3374-3385 (1994).
Hodgson et al., "Probing the hammerhead robozyme structure with ribonucleases," Nucleic Acids Research 22:1620-1625 (1994).
Igloi et al., "Interaction of tRNAs and of Phosphorothioate-Substituted Nucleic Acids with an Organomercurial. Probing the Chemical Environment of Thiolated Residues by Affinity Electrophoresis," Biochemistry 27:3842-3849 (1988).
Ishiwata et al., "Physical-Chemistry Characteristics and Biodistribution of Poly(ethylene glycol)-Coated Liposomes Using Poly(oxyethylene) Cholesteryl Ether," Chem. Pharm. Bull. 43:1005-1011 (1995).
Ishizaka et al., "Isolation of Active Ribozymes from an RNA Pool of Random Sequences Using an Anchored Substrate RNA," Biochemical and Biophysical Research Communication 214(2):403-409 (1995).
Izant and Weintraub, "Constitutive and Conditional Suppression of Exogenous and Endogeneous Genes by Anti-Sense RNA, " Science 229:345-352 (1985).
Jaschke et al., "Automated Incorporation of Polyethylene Glycol into Synthetic Oligonucleotides," Tetrahedron Letters 34:301-304 (1993) (Jaschke).
Jeffries and Symons, "A Catalytic 13-mer Ribozyme," Nucleic Acids Research 17:1371-1377 (1989) (also referred to as Jefferies).
Joseph and Burke, "Optimization of an Anti-HIV Hairpin Ribozyme by in Vitro Selection," J. Biol. Chem. 268:24510-24518 (1993).
Joyce et al., "Amplication, Mutation and selection of catalytic RNA," Gene 82:83-87 (1989).
Joyce, "Directed Molecular Evolution," Scientific American 267:90-97 (1992).
Kashani-Sabet et al., "Reversal of the Malignant Phenotype by an Anti-ras Ribozyme," Anitsense Research & Development 2:3-15 (1992).
Kumar and Ellington,"Artificial evolution and natural ribozymes," FASEB J. 9:1183-1195 (1995).
Lasic and Needham "The `Steath` Liposome: A Prototypical Biomaterial," Chemical Reviews 95:2601-2627 (1995).
Lasic and Papahadjopoulos, "Liposomes Revisited," Science 267:1275-1276 (1995).
L'Huillier et al., "Cytoplasmic Delivery of Ribozymes Leads to Efficient Reduction in .alpha.-Lactalbumin mRNA Levels in C1271 Mouse," EMBO J. 11:4411-4418 (1992).
Lieber et al., "Stable High-Level Gene Expression in Mammalian Cells by T7 Phage RNA Polymerase," Methods Enzymol. 217:47-66 (1993).
Limbach et al., "Summary: the modified nucleosides of RNA, " Nucleic Acids Research 22(12):2183-2196 (1994).
Lisziewicz et al., "Inhibition of Human Immunodeficiency Virus Type 1 Replication by Regulated Expression of a Polymeric Tat Activation Response RNA Decoy as a Stategy for Gene Therapy in AIDS," Proc. Natl. Acad. Sci. U.S.A. 90:8000-8004 (1993).
Liu et al., "Cationic Liposome-mediated Intravenous Gene Delivery," J. Biol. Chem. 270(42):24864-24870 (1995).
Long and Uhlenbeck, "Kinetic characterization of intramolecular and intermolecular hammerhead RNAs with stem II deletions," Proc. Natl. Acad. Sci. USA 91:6977-6981 (1994).
Loria and Pan, "Domain Structure of the ribozyme from eubacterial ribonuclease P," RNA 2:551-563 (1996).
Ma et al., "Design and Sythesis of RNA Miniduplexes via a Synthetic Linker Approach. 2. Generation of Convalently Closed, Double-Stranded Cyclic HIV-1 TAR RNA Analogs with High Tat-Binding Affinity, " Nucleic Acids Research 21:2585-2589 (1993).
Ma et al., "Design and Synthesis of RNA Miniduplexes via a Synthetic Linker Approach
Eckstein Fritz
Heaton Paul A.
Vaish Narendra K.
Epps Janet
Ribozyme Pharmaceuticals Inc.
Schwartzman Robert A.
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