Nucleic acid capable of binding specifically to Ras target...

Details Nucleic acid capable of binding specifically to Ras target... Nucleic acid capable of binding specifically to Ras target...

2006-02-07

2006-02-07

Horlick, Kenneth R. (Department: 1637)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C536S024100, C536S024300, C536S024320

Reexamination Certificate

active

06995249

ABSTRACT:
A novel nucleic acid (aptamer) which binds specifically to the target protein of Ras, more particularly, a novel RNA aptamer which binds specifically to Raf-1; a method for screening an RNA capable of binding specifically to the target protein of Ras which comprises selecting an RNA capable of binding to the target protein of Ras from a pool of RNAs having various base sequences; a method for regulating the signal transduction causing the proliferation or differentiation of cells by using the above-described nucleic acid; and medicinal compositions with the use of the same.

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Hudson et al., “Screening for inhibitors or ras-protein partner interactions- using a ras-binding domain coated on scintillation plates and tritium-labelled GTP,”Zeneca Pharm. Cancer Res. Dept. (1995) Abstract XP-002246369.
Michiko Kimoto et al., “RNA aptamers that specifically bind to the Ras-binding domain of Raf-1”, FEBS Letters, 441(2):322-326 (1998).
Walter Kolch et al., “Inhabition of Raf-1 signaling by a monoclonal antibody, which interferes with Raf-1 activation and with Mek substrate binding”, Oncogene, 13(6):1305-1314 (1996).
Andrew D. Ellington et al., “In vitro selection of RNA molecules that bind specific ligands”, Nature, 346(6287):818-822 (1990).
Craig Tuerk et al., “Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase”, Science, 249(4968):505-510 (1990).

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