Nucleic acid binding proteins

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S007100, C435S091100, C536S023100, C530S350000

Reexamination Certificate

active

10853437

ABSTRACT:
Disclosed herein are methods for designing DNA binding proteins comprising a plurality of zinc fingers and methods for binding the proteins to target nucleotide sequences in cells.

REFERENCES:
patent: 4990607 (1991-02-01), Katagiri et al.
patent: 5096814 (1992-03-01), Aivasidis et al.
patent: 5096815 (1992-03-01), Ladner et al.
patent: 5198346 (1993-03-01), Ladner et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5243041 (1993-09-01), Fernandez-Pol
patent: 5302519 (1994-04-01), Blackwood et al.
patent: 5324638 (1994-06-01), Tao et al.
patent: 5324818 (1994-06-01), Nabel et al.
patent: 5324819 (1994-06-01), Oppermann et al.
patent: 5340739 (1994-08-01), Stevens et al.
patent: 5348864 (1994-09-01), Barbacid
patent: 5350840 (1994-09-01), Call et al.
patent: 5356802 (1994-10-01), Chandrasegaran
patent: 5376530 (1994-12-01), De The et al.
patent: 5403484 (1995-04-01), Ladner et al.
patent: 5436150 (1995-07-01), Chandrasegaran
patent: 5487994 (1996-01-01), Chandrasegaran
patent: 5498530 (1996-03-01), Schatz et al.
patent: 5578483 (1996-11-01), Evans et al.
patent: 5597693 (1997-01-01), Evans et al.
patent: 5639592 (1997-06-01), Evans et al.
patent: 5674738 (1997-10-01), Abramson et al.
patent: 5702914 (1997-12-01), Evans et al.
patent: 5789538 (1998-08-01), Rebar et al.
patent: 5792640 (1998-08-01), Chandrasegaran
patent: 5869618 (1999-02-01), Lippman et al.
patent: 5871902 (1999-02-01), Weininger et al.
patent: 5871907 (1999-02-01), Winter et al.
patent: 5916794 (1999-06-01), Chandrasegaran
patent: 5939538 (1999-08-01), Leavitt et al.
patent: 5972615 (1999-10-01), An et al.
patent: 6001885 (1999-12-01), Vega et al.
patent: 6007988 (1999-12-01), Choo et al.
patent: 6013453 (2000-01-01), Choo et al.
patent: 6746838 (2004-06-01), Choo et al.
patent: 6866997 (2005-03-01), Choo et al.
patent: 875 567 (1998-11-01), None
patent: WO 95/19431 (1995-07-01), None
patent: WO 96/06110 (1996-02-01), None
patent: WO 96/06166 (1996-02-01), None
patent: WO 96/11267 (1996-04-01), None
patent: WO 96/20951 (1996-07-01), None
patent: WO 96/32475 (1996-10-01), None
patent: WO 97/27212 (1997-07-01), None
patent: WO 97/27213 (1997-07-01), None
patent: WO 98/53057 (1998-11-01), None
patent: WO 98/53058 (1998-11-01), None
patent: WO 98/53059 (1998-11-01), None
patent: WO 98/53060 (1998-11-01), None
patent: WO 98/54311 (1998-12-01), None
patent: WO 99/36553 (1999-07-01), None
patent: WO 99/41371 (1999-08-01), None
patent: WO 99/42474 (1999-08-01), None
patent: WO 99/45132 (1999-09-01), None
patent: WO 99/47656 (1999-09-01), None
patent: WO 99/48909 (1999-09-01), None
Agarwal et al., “Stimulation of Transcript Elongation Requires both the Zinc Finger and RNA Polymerase II Binding Domains of Human TFIIS,”Biochemistry, 30(31):7842-7851 (1991).
Anato et al., “A thermodynamic study of unusually stable RNA and DNA hairpins,”Nuc. Acids. Res., 19(21):5901-5905 (1991).
Barbas, C. F., “Recent advances in phage display,”Curr. Opin. Biotech., 4:526-530 (1993).
Barbas et al., “Assembly of combinatorial antibody libraries on phage surfaces: The gene III site,”PNAS, 88:7978-7982 (1991).
Barbas et al., “Semisynthetic combinatorial antibody libraries: A chemical solution to the diversity problem,”PNAS, 89:4457-4461 (1992).
Bellefroid et al., “Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells,”EMBO J., 12(4):1363-1374 (1993).
Berg, J. M., “DNA Binding Specificity of Steroid Receptors,”Cell, 57:1065-1068 (1989).
Berg, J. M., “Sp1 and the subfamily of zinc finger proteins with guanine-rich binding sites,”PNAS, 89:11109-11110 (1992).
Berg et al., “The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc,”Science, 271:1081-1085 (1996).
Berg, J. M., “Letting your fingers do the walking,”Nature Biotechnology, 15:323 (1997).
Bergqvist et al., “Loss of DNA-binding and new transcriptionaltrans-activation function in polyomavirus large T-antigen with mutation of zinc finger motif,”Nuc. Acids Res., 18(9):2715-2720 (1990).
Blaese et al., “Vectors in cancer therapy: how will they deliver?,”Cancer Gene Therapy, 2(4):291-297 (1995).
Bonde et al., “Ontogeny of the v-erb AOncoprotein from the Thyroid Hormone Receptor: an Alteration in the DNA Binding Domain Plays a Role Crucial for v-erb AFunction,”J. Virology, 65(4):2037-2046 (1991).
Caponigro et al., “Transdominant genetice analysis of a growth control pathway,”PNAS, 95:7508-7513 (1998).
Celenza et al., “A Yeast Gene That Is Essential for Release from Glucose Repression Encodes a Protein Kinase,”Science, 233:1175-1180 (1986).
Cheng et al., “Identification of Potential Target Genes for Adr1p through Characterization of Essential Nucleotides in UAS1,”Mol. Cellular Biol., 14(6):3842-3852 (1994).
Cheng et al., “A Single Amino Acid substitution in Zinc Finger 2 of Adr1p Changes its Binding Specificity at two Positions in UAS1,”J. Mol. Biol., 251:1-8 (1995).
Choo et al., “A role in DNA binding for the linker sequences of the first three zinc fingers of TFIIIA,”Nuc. Acids Res., 21(15):3341-3346 (1993).
Choo et al., “Designing DNA-binding proteins on the surface of filamentous phage,”Curr. Opin. Biotech., 6:431-436 (1995).
Choo et al., “Promoter-specific Activation of Gene Expression Directed by Bacteriophage-selected Zinc Fingers,”J. Mol. Biol., 273:525-532 (1997).
Choo, Y., “Recognition of DNA methylation by zinc fingers,”Nature Struct. Biol., 5(4):264-265 (1998).
Choo et al., “All wrapped up,”Nature Structural Biology, 5(4):253-255 (1998).
Choo, Y., “End effects in DNA recognition by zinc finger arrays,”Nuc. Acids Res., 26(2):554-557 (1998).
Choo et al., “In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence,”Nature, 372:642-645 (1994).
Choo et al., “Physical basis of a protein-DNA recognition code,”Curr. Opin. Struct. Biol., 7(1):117-125 (1997).
Choo et al., “Toward a code for the interactions of zinc fingers with DNA: Selection of randomized fingers displayed on phage,”PNAS, 91:11163-11167 (1994).
Choo et al., “Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions,”PNAS, 91:11168-11172 (1994).
Corbi, N. et al., “Synthesis of a New Zinc Finger Peptide; Comparison of its ‘Code’ Deduced and ‘CASTing’ Derived Binding Sites,”FEBS Letters, 417: 71-74 (1997).
Crozatier et al., “Single Amino Acid Exchanges in Separate Domains of the Drosophila serendipity δ Zinc Finger Protein Cause Embryonic and Sex Biased Lethality,”Genetics, 131:905-916 (1992).
Debs et al., “Regulation of Gene Expression in Vivo by Liposome-mediated Delivery of a Purified Transcription Factor*,”J. Biological Chemistry, 265(18):10189-10192 (1990).
Desjarlais et al., “Length-encoded multiplex binding site determination: Application to zinc finger proteins,”PNAS, 91:11099-11103 (1994).
Desjarlais et al., “Use of a zinc-finger consensus sequence framework and specificity rules to design specific DNA binding proteins,”PNAS, 90:2256-2260 (1993).
Desjarlais et al., “Toward rules relating zinc finger protein sequences and DNA binding site preferences,”PNAS, 89(16):7345-7349 (1992).
Desjarlais et al., “Redesigning the DNA-Binding Specificity of a Zinc Finger Protein: A Data Base-Guided Approach,”Proteins: Structure, Function, and Genetics, 12(2):101-104 (1992).
Desjarlais et al., “Redesigning the DNA-Binding Specificity of a Zinc Finger Protein: A Data Base-Guided Approach,”Proteins: Structure, Function, and Genetics, 13:272 (1992).
Desjardins et al., “Repeated CT Elements Bound by Zinc Finger Proteins Control the Absolute and Relative Ac

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