Nucleic acid binding proteins

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S006120, C435S007100, C536S023100, C530S350000

Reexamination Certificate

active

06866997

ABSTRACT:
Disclosed herein are methods of designing zinc finger binding polypeptides for binding to particular target sequences comprising overlapping nucleotide quadruplets.

REFERENCES:
patent: 4990607 (1991-02-01), Katagiri et al.
patent: 5096814 (1992-03-01), Aivasidis et al.
patent: 5096815 (1992-03-01), Ladner et al.
patent: 5198346 (1993-03-01), Ladner et al.
patent: 5223409 (1993-06-01), Ladner et al.
patent: 5243041 (1993-09-01), Fernandez-Pol
patent: 5302519 (1994-04-01), Blackwood et al.
patent: 5324638 (1994-06-01), Tao et al.
patent: 5324818 (1994-06-01), Nabel et al.
patent: 5324819 (1994-06-01), Oppermann et al.
patent: 5340739 (1994-08-01), Stevens et al.
patent: 5348864 (1994-09-01), Barbacid
patent: 5350840 (1994-09-01), Call et al.
patent: 5356802 (1994-10-01), Chandrasegaran
patent: 5376530 (1994-12-01), De The et al.
patent: 5403484 (1995-04-01), Ladner et al.
patent: 5436150 (1995-07-01), Chandrasegaran
patent: 5487994 (1996-01-01), Chandrasegaran
patent: 5498530 (1996-03-01), Schatz et al.
patent: 5578483 (1996-11-01), Evans et al.
patent: 5597693 (1997-01-01), Evans et al.
patent: 5639592 (1997-06-01), Evans et al.
patent: 5674738 (1997-10-01), Abramson et al.
patent: 5702914 (1997-12-01), Evans et al.
patent: 5789538 (1998-08-01), Rebar et al.
patent: 5792640 (1998-08-01), Chandrasegaran
patent: 5869618 (1999-02-01), Lippman et al.
patent: 5871902 (1999-02-01), Weininger et al.
patent: 5871907 (1999-02-01), Winter et al.
patent: 5916794 (1999-06-01), Chandrasegaran
patent: 5939538 (1999-08-01), Leavitt et al.
patent: 5972615 (1999-10-01), An et al.
patent: 6001885 (1999-12-01), Vega et al.
patent: 6007988 (1999-12-01), Choo et al.
patent: 6013453 (2000-01-01), Choo et al.
patent: 875 567 (1998-11-01), None
patent: WO 9519431 (1995-07-01), None
patent: WO 9606110 (1996-02-01), None
patent: 96 06166 (1996-02-01), None
patent: WO 9606166 (1996-02-01), None
patent: WO 9611267 (1996-04-01), None
patent: WO 9620951 (1996-07-01), None
patent: WO 9732475 (1996-10-01), None
patent: WO 9727212 (1997-07-01), None
patent: WO 9727213 (1997-07-01), None
patent: WO 9853057 (1998-11-01), None
patent: WO 9853058 (1998-11-01), None
patent: WO 9853059 (1998-11-01), None
patent: WO 9853060 (1998-11-01), None
patent: WO 9854311 (1998-12-01), None
patent: WO 9936553 (1999-07-01), None
patent: WO 9941371 (1999-08-01), None
patent: WO 9942474 (1999-08-01), None
patent: WO 9945132 (1999-09-01), None
patent: WO 9947656 (1999-09-01), None
patent: WO 9948909 (1999-09-01), None
Krizek et al. A consensus zinc finger peptide: design, high-affinity metal binding, a pH-dependent structure, and a His to Cys sequence variant. J. Am. Chem. Soc.; 1991; 113(12); 4518-4523. (Abstract).*
Bonde et al., “Ontogeny of thev-erb AOncoprotein from the Thyroid Hormone Receptor: an Alteration in the DNA Binding Domain Plays a Role Crucial forv-erb AFunction,”J. Virology,65(4):2037-2046 (1991).
Desjardins et al., “Repeated CT Elements Bound by Zinc Finger Proteins Control the Absolute and Relative Activities of the Two Principal Humanc-mysPromoters,”Mol. and Cellular Biol., 13(9):5710-5724 (1993).
Hall et al., “Functional Interaction between the Two Zinc finger Domains of the v-erb A Oncoprotein,”Clee Growth&Differentiation, 3:207-216 (1992).
Isalan et al: “Synergy between adjacent zinc fingers in sequence-specific DNA recognition” Proceedings of the National Academy of Sciences of USA, vol. 94, May 27, 1997 pp. 5617-5621, XP002075337.
Y. Choo, A. Klug: “Physical basis of a protein-DNA recognition code” Curr. Op. Struct. Biol., vol. 7, No. 1, Feb. 1997, pp. 117-125, XP002075338.
Choo Y et al.: “Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions.” Proceedings of the Nationa Academy of Sciences of the United Staes of America 91 (23). 1994. 11168-11172. ISSN: 0027-8424, Nov. 8, 1994, XP002075339.
Choo Y. et al.: “Toward a code for the interactions of zinc fingers with DNA: Selection of randomized fingers displayed on phage.” Proceedings of the National Academy of Sciences of The United States of America 91 (23). 1994. 11163-11167. ISSN: 0027-8424, Nov. 8, 1994, XP002075340.
M. Elrod-Erickson et al.: “Zif268 protein-DNA complex refined at 1.6A: a model system for understanding zinc finger-DNA interactions” STRUCTURE, vol. 4, No. 10, 1996, pp. 1171-1180, ZP002075347.
Agarwal et al., “Stimulation of Transcript Elongation Requires both the Zinc Finger and RNA Polymerase II Binding Domains of Human TFIIS,”Biochemisry,30(31):7842-7851 (1991).
Anato et al., “A thermodynamic study of unusually stable RNA and DNA hairpins,”Nuc. Acids. Res.,19(21):5901-5905 (1991).
Barbas, C. F., “Recent advances in phage display,”Curr. Opin. Biotech., 4:526-530 (1993).
Barbas et al., “Assembly of combinatorial antibody libraries on phage surfaces: The gene III site,”PNAS,88:7978-7982 (1991).
Barbas et al., “Semisynthetic combinatorial antibody libraries: A chemical solution to the diversity problem,”PNAS, 89:4457-4461 (1992).
Bellefroid et al., “Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells,”EMBO J., 12(4):1363-1374 (1993).
Berg, J. M., “DNA Binding Specificity of Steriod Receptors,”Cell, 57:1065-1068 (1989).
Berg, J. M., “Sp1 and the subfamily of zinc finger proteins with guanine-rich binding sites,”PNAS, 89:11109-11110 (1992).
Berg et al., “The Galvanization of Biology: A Growing Appreciation for the Roles of Zinc,”Science, 271:1081-1085 (1996).
Berg, J. M., “Letting your fingers do the walking,”Nature Biotechnology, 15:323 (1997).
Bergqvist et al., “Loss of DNA-binding and new transcriptionaltrans-activation function in polyomavirus large T-antigen with mutation of zinc finger motif,”Nuc. Acids Res., 18(9):2715-2720 (1900).
Blaese et al., “Vectors in cancer therapy: how will they deliver?,”Cancer Gene Therapy, 2(4):291-297 (1995).
Caponigro et al., “Transdominant genetice analysis of a growth control pathway,”PNAS,95:7508-7513 (1998).
Celenza et al., “A Yeast Gene That Is Essential for Release from Glucose Repression Encodes a Protein Kinase,”Science, 233:1175-1180 (1986).
Cheng et al., “Identification of Potential Target Genes for Adr1p through Characterization of Essential Nucleotides in UAS1,”Mol. Cellular Biol., 14(6):3842-3852 (1994).
Cheng et al., “A Single Amino Acid substitution in Zinc Finger 2 of Adr1p Changes its Binding Specificity at two Positions in UAS1,”J. Mol. Biol., 251:1-8 (1995).
Choo et al., “A role in DNA binding for the linker sequences of the first three zinc fingers of TFIIIA,”Nuc. Acids Res., 21(15):3341-3346 (1993).
Choo et al., “Designing DNA-binding proteins on the surface of filamentous phage,”Curr. Opin. Biotech., 6:431-436 (1995).
Choo et al., “Promoter-specific Activation of Gene Expression Directed by Bacteriophage-selected Zinc Fingers,”J. Mol. Biol., 273:525-532 (1997).
Choo, Y., “Recognition of DNA methylation by zinc fingers,”Nature Struc. Biol., 5(4):264-265 (1998).
Choo et al., “All wrapped up,”Nature Structural Biology, 5(4):253-255 (1998).
Choo, Y., “End effects in DNA recognition by zinc finger arrays,”Nuc. Acids Res., 26(2):554-557 (1998).
Choo et al., “In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence,”Nature, 372:642-645 (1994).
Corbi, N. et al., “Synthesis of a New Zinc Finger Peptide; Comparison of its ‘Code’ Deduced and ‘CASTing’ Derived Binding Sites,”FEBS Letters, 417: 71-74 (1997).
Crozatier et al., “Single Amino Acid Exchanges in Separate Domains of the Drosophila serendipity δ Zinc Finger Protein Cause Embryonic and Sex Biased Lethali

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nucleic acid binding proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acid binding proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid binding proteins will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3406794

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.