Nucleic acid-binding oligomers possessing N-branching for therap

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 243, 536 187, 536 245, 544242, 544244, 544264, 562575, C07K 700, C07H 504, C07H 2104, C07D23900

Patent

active

056230494

ABSTRACT:
The invention relates to nucleic acid-binding oligomers possessing N-branching of the general formula (I), ##STR1## and their monomers, where the individual radicals have the meaning given in the description, and to their use as medicaments or as aids in diagnostics.

REFERENCES:
B. Hyrup et al., J. Am. Chem. Soc. 116 ('94) 7964-70.
H. Kang et al., Biopolymers ('92) 32(10) 1351-63 Abstract.
R. McGraw et al., BioTechniques, 8(6) ('90) 674-8.
F. Flan, Science, vol. 262 (Dec. 10, 1993) 1647-49.
E. Uhlmann et al., Chemical Rev., 90(4) ('90) 543-584.
C. Stein et al., Science, 261 (Aug. 20, 1993) 1004-1012.
J. Milligan et al., J. Med. Chem. (93) 36(14) 1923-37.
P. Nielsen et al., Science, 254 (Dec. 6, 1991) 1497-1500.
C. Helene et al., B. B. Aora 1049 ('90) 99-125.
Chemical Abstracts, vol. 94, Feb. 2, 1981, No. 5, pp. 1/185; CA# 26354j: "Specific interaction between oligovaline . . . ", S.A. Strel'tsov et al.
Chemical Abstracts, vol. 113, Nov. 19, 1990, No. 21; pp. 1/776; CA# 191856t: "Preparation of oligodeoxyribonucleotide . . . ", P. Westermann et al.
Elsevier Science Publishers LTD, Tibtech, May 1992, vol. 10, pp. 152-158; "Antisense oligonucleotides as antiviral agents", S. Agrawal.
Antiviral Chemistry & Chemotherapy, vol. 2, No. 4, 1991, pp. 191-214; "Towards gene-inhibition therapy: a review of progress . . . ", W. James.
Cancer Research, vol. 51, Sep. 1, 1991, pp. 4505-4510; "Inhibition of Protooncogene expression by antisense oligodeoxynucleotides . . . ", B. Calabretta.
Anti-Cancer Drug Design, 1991, vol. 6, pp. 569-584; "The anti-gene strategy: control of gene expression by triplex-. . . ", C. H el ene.
Chemical Reviews, American Chemical Society, Jun. 1990, vol. 90, No. 4, pp. 544-584/cover page; "Antisense Oligonucleotides: a new . . . ", E. Uhlmann et al.
The Journal of Organic Chemistry, vol. 33, No. 4, Apr. 1968, pp. 1341-1344; "N-vinyl derivatives of substituted pyrimidines . . . ", J. Pitha et al.
Advances in polymer Science 50, Springer-Verlag Berlin Heidelberg, 1983, pp. 1-16; "Physiological activities of synthetic analogs . . . ", J. Pitha.
Tetrahedron Letters, vol. 32, No. 50, pp. 7385-7388, 1991; "Solid phase synthesis of neutral oligonucleotide analogues", H. Wang et al.
Tetrahedron Letters, vol. 34, No. 8, pp. 1275-1278, 1993; "Peptide-based nucleic acid surrogates incorporating . . . ", P. Garner et al.
J. Org. Chem., 1991, vol. 56, pp. 6007-6018; "Acyclic nucleic acid analogues: synthesis and oligomerization of . . . ", S.B. Huang et al.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nucleic acid-binding oligomers possessing N-branching for therap does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acid-binding oligomers possessing N-branching for therap, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid-binding oligomers possessing N-branching for therap will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-342571

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.