Nucleic acid binding enhancement by conjugation with...

Details Nucleic acid binding enhancement by conjugation with... Nucleic acid binding enhancement by conjugation with...

2005-08-02

2005-08-02

Forman, BJ (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C536S023100, C536S024320, C536S024330

Reexamination Certificate

active

06924108

ABSTRACT:
An improved method of forming a specific complex between a probe containing probe nucleobases and a target containing target nucleobases, includes mixing the probe and the target under hybridizing conditions, wherein the probe and/or the target is conjugated to a blocking agent, which enhances the avidity and/or specificity of hybridization, whether by Watson-Crick motif or by homologous binding motif. The blocking agent contains at least one nucleobase and can be, e.g., a free nucleobase, a nucleoside or a nucleotide.

REFERENCES:
patent: 4220450 (1980-09-01), Maggio
patent: 4876187 (1989-10-01), Duck et al.
patent: 4963477 (1990-10-01), Tchen
patent: 5011769 (1991-04-01), Duck et al.
patent: 5030557 (1991-07-01), Hogan et al.
patent: 5332659 (1994-07-01), Kidwell
patent: 5403711 (1995-04-01), Walder et al.
patent: 5538848 (1996-07-01), Livak et al.
patent: 5539082 (1996-07-01), Nielsen et al.
patent: 5558998 (1996-09-01), Hammond et al.
patent: 5660988 (1997-08-01), Duck et al.
patent: 5705346 (1998-01-01), Okamoto et al.
patent: 5707801 (1998-01-01), Bresser et al.
patent: 5720928 (1998-02-01), Schwartz
patent: 5731146 (1998-03-01), Duck et al.
patent: 5770365 (1998-06-01), Lane et al.
patent: 5800984 (1998-09-01), Vary
patent: 5800992 (1998-09-01), Fodor et al.
patent: 5814447 (1998-09-01), Ishiguro et al.
patent: 5814516 (1998-09-01), Vo-Dinh
patent: 5824477 (1998-10-01), Stanley
patent: 5824557 (1998-10-01), Burke et al.
patent: 5846729 (1998-12-01), Wu et al.
patent: 5861124 (1999-01-01), Hosoi et al.
patent: 5874555 (1999-02-01), Dervan et al.
patent: 5888739 (1999-03-01), Pitner et al.
patent: 5912332 (1999-06-01), Agrawal et al.
patent: 5948897 (1999-09-01), Sen et al.
patent: 6013443 (2000-01-01), Heilig et al.
patent: 6017709 (2000-01-01), Hardin et al.
patent: 6027880 (2000-02-01), Cronin et al.
patent: 6046004 (2000-04-01), Wu et al.
patent: 6048690 (2000-04-01), Heller et al.
patent: 6060242 (2000-05-01), Nie et al.
patent: 6107078 (2000-08-01), Keese et al.
patent: 6117657 (2000-09-01), Usman et al.
patent: 6130038 (2000-10-01), Becker et al.
patent: 6147198 (2000-11-01), Schwartz
patent: 6251591 (2001-06-01), Wu et al.
patent: 6255050 (2001-07-01), Nie et al.
patent: 6255469 (2001-07-01), Seeman et al.
patent: 6265170 (2001-07-01), Picard et al.
patent: 6287772 (2001-09-01), Stefano et al.
patent: 6312925 (2001-11-01), Meyer, Jr. et al.
patent: 2333359 (1999-07-01), None
patent: 2338301 (1999-12-01), None
patent: WO 97/45539 (1997-12-01), None
patent: WO 00/20633 (2000-04-01), None
Astract of JP 5237000, Yoshitami (Sep. 17, 1993).
Baran et al.,Nucleic Acids Research25:297-303 (1997).
Bohmann et al.,Science, 238:1386-1392 (Dec. 1987).
Carlsson et al., 380Nature207 (Mar. 21, 1996).
Chan et al.,J. Mol. Med.75 Issue 4:267-282 (1997).
Dalrymple et al.,Nucleic Acids Research, vol. 13, No. 21, pp. 7865-7879 (1985).
Durland et al.,Biochemistry, 30:9246-9255 (1991).
Egholm et al., 365Nature566 (Oct. 7, 1993).
Floris et al., 260Eur. J. Biochem.801-809 (1999).
Hill et al.,Methods in Enzymology, 278:390-416 (1997).
Johansen and Jacobsen,J Biomol Struct Dyn, 16(2):205-22 (Oct 1998) (Abstract).
Kadonaga et al.,Cell, 51:1079-1090 (Dec. 24, 1987).
Kukreti et al. 25Nucleic Acids Research4264-4270 (1997).
Marsh et al.,Nucleic Acids Research, 23:696-700 (1995).
Marsh et al.,Biochemistry33:10718-10724 (1994).
Mazumder et al.,Biochemistry35:13762-13771 (1996).
Rocher, Christophe et al.,Nucleic Acids Research, “Initiation of DNA replication by DNA polymerases from primers forming a triple helix,” 2001, vol. 29, No. 16, 3320-3326.
Sen et al.,Nature334:364-366 (Jul. 28, 1988).
Sen et al.,Biochemistry31:65-70 (1992).
Sturm et al.,Genes&Development, 2:1582-1599 (1988).
Tomac et al., 118J. Am. Chem. Soc.5544-5552 (1996).
Watson, James, “A Personal Account of the Discovery of the Structure of DNA,” (1968).
Williamson et al.,Cell59:871-880 (Dec. 1, 1989).
Wilson et al.,Cell, 74:115-125 (Jul. 16, 1993).
Zhurkin et al.,J. Mol. Biol., vol. 239, 181-200 (1994).
Riccelli et al., “Hybridization of single-stranded DNA targets to immobilized complementary DNA probes: comparison of hairpin versus linear capture probes.” Nucleic Acids Res Feb. 15, 2001;29(4):996-1004.

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