Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-04-19
2005-04-19
Wilson, James O. (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S025600, C514S046000, C514S047000, C514S048000, C514S049000
Reexamination Certificate
active
06881831
ABSTRACT:
The invention provides compounds capable of treating against hepatitis infections, particularly hepatitis B viral infections. Compounds of the invention are nucleic acid-based and preferably comprise 2, 3, 4, 5 or 6 nucleoside units.
REFERENCES:
patent: 5149798 (1992-09-01), Agrawal et al.
patent: 5212295 (1993-05-01), Cook
patent: 5218103 (1993-06-01), Caruthers et al.
patent: 5843912 (1998-12-01), Hosmane et al.
patent: WO 9012578 (1990-11-01), None
patent: WO 9639154 (1996-12-01), None
patent: WO 9639502 (1996-12-01), None
patent: WO 0140515 (2001-06-01), None
patent: WO 2002043771 (2002-06-01), None
patent: WO 02081494 (2002-10-01), None
Agrawal, S., et al., “Antisense oligonucleotides as antiviral agents,” Trends in Biotechnology 10(5): 152-158, May 1992.*
Monkkonen et al., Advanced Drug Delivery Systems, vol. 34(1), pp. 37-49.*
Agrawal, S., “Antisense oligonucleotides as antiviral agents,”Trends in Biotechnology 10(5): 152-158, May 1992.
Agrawal, S. et al., “Oligodeoxynucleoside phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus,”Proc. Natl. Acad. Sci. USA 85(19): 7079-7083, Oct. 1988.
Beaucage, S.L., “Oligodeoxyribonucleotides synthesis. Phosphoramidite approach,”Methods Mol. Biol. 20: 33-61, 1993.
Benseler, F. et al., “Hammerhead-like molecules containing non-nucleoside linkers are active RNA catalysts,”Journal of the American Chemical Society 115(18): 8483-8484, Sep. 8, 1993.
Bergot and Egan, “Separation of synthetic phophorothioate oligodeoxynucleotides from their oxygenated (phosphodiester) defect species by strong-anion-exchange high-performance liquid chromatography,”Journal of Chromatography 599(1-2): 35-42, May 22, 1992.
Caruthers, M.H. et al., “Chemical synthesis of deoxyoligonucleotides by the phosphoramidite method,”Methods in Enzymology 154: 287-313, 1987.
Froehler, B.C., “Deoxynucleoside H-phosphonate diester intermediates in the synthesis of internucleotide phosphate analogs,”Tetrahedron Letters 27(46): 5575-5578, 1986.
Goodchild, J., “Conjugates of oligonucleotides and modified oligonucleotides: a review of their synthesis and properties,”Bioconjugate Chemistry 1(3): 165-187, May/Jun. 1990.
Hoofnagle, J.H., “Chronic hepatits B,”New England Journal of Medicine 323(5):337-339, Aug. 2, 1990.
Letsinger and Wu, “Use of a stilbenedicarboxamide Bridge in Stabilizing, Monitoring, and Photochemically Altering Folded Conformations of Oligonucleotides,”Journal of the American Chemical Society 117(28): 7323-7328, Jul. 19, 1995.
Uhlmann and Anusch, “Antisense oligonucleotides: a new therapeutic principle,”Chemical Reviews 90(4): 543-584, Jun. 1990.
X Ma, M.Y. et al., “Design and synthesis of RNA miniduplexes via a synthetic linker approach. 2. generation of covalently closed, double-stranded cyclic HIV-1 TAR RNA analogs with high Tat-binding affinity,”Nucleic Acids Research 21(11): 2585-2589, Jun. 11, 1993.
Jin, Yi, et al., “Parallel Solid-Phase Synthesis of Nucleoside Phosphoramidate Libraries,”Bioorganic&Medical Chemistry Letters, 11: 2057-2060 (2001).
Asseline, Ulysse, et al., “Synthesis and Binding Properties of Oligonucleotides Covalently Linked to an Acridine Derivative: New Study of the Influence of the Dye Attachment Site,”Bioconjugate Chem., 7: 369-379 (1996).
Kumar, Prabhat, and Misra, K., “A New Strategy for the Synthesis of Phosphorothioates of 2′-Deoxyriboligonucleotides,”Indian J. of Chemistry, 36B: 1000-1004 (1997).
Ravikumar, Vasulinga T., et al., “4-Cyano-2-Butenyl Group: A New Type of Protecting Group in Oligonucleotide Synthesis Via Phosphoramidite Approach,”Nucleosides&Nucleotides, 16(7-9): 1709-1712 (1997).
Brill, Wolfgang K.-D., et al., “Synthesis of Oligodeoxynucleoside Phosphorodithioates via Thioamidites,”J. Am. Chem. Soc., 111: 2321-2322 (1989).
Iyer Radhakrishnan P.
Jin Yi
Roland Arlène
Zhou Wenqiang
Craig, P.C. Elmore
Elmore Carolyn S.
Migenix Inc.
Owens Howard V.
Vanstone Darlene A.
LandOfFree
Nucleic acid-based compounds and methods of use thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid-based compounds and methods of use thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid-based compounds and methods of use thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3375853