Nucleic acid and recombinant production of vespid venom hyaluron

Details Nucleic acid and recombinant production of vespid venom hyaluron Nucleic acid and recombinant production of vespid venom hyaluron

1994-01-11

1997-01-14

Walsh, Stephen G.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435 691, 4353201, 536 232, 536 235, 536 2431, C12N 1555, C12N 1570

Patent

active

055938779

ABSTRACT:
The present invention is directed to nucleic acids encoding vespid venom enzymes, or fragments thereof, recombinant vectors comprising such nucleic acids, and host cells containing the recombinant vectors. The invention is further directed to expression of such nucleic acids to produce recombinant vespid venom enzymes, or recombinant fragments, derivatives or analogs thereof. Such recombinant products are useful for diagnosis of allergy and for therapeutic treatment of allergy. In specific embodiments, the present invention provides nucleic acids encoding, and complete nucleotide and amino acids sequences for, vespid venom phospholipase, for example, Dolichovespula maculata phospholipase and Vespula vulgaris phospholipase, and vespid venom hyaluronidase, for example, Dolichovespula maculata hyaluronidase.

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