Nucleic acid and amino acid sequences of infectious salmon...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Virus or component thereof

Reexamination Certificate

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C424S186100, C424S204100

Reexamination Certificate

active

07128917

ABSTRACT:
The present invention provides the use of nucleic acid sequences and/or amino acid sequences in the preparation of a vaccine for the protection of fish against infectious salmon anaemia virus. Specifically, such vaccines contain at least one nucleic acid sequence which is derived from ISAV or synthetically prepared analogues thereof, or substantially homologous sequences. These nucleic acid sequences are transcripted and translated into peptide sequences which are incorporated into a vaccination strategy to induce and immune response to the surface antigens of ISAV and therefore ISAV itself. Therefore both the use of a vaccine against ISAV, and the incorporation of peptide sequences is herein described.

REFERENCES:
patent: 6471964 (2002-10-01), Biering et al.
patent: WO/00/72878 (2000-12-01), None
patent: WO/01/49712 (2001-01-01), None
patent: WO/01/66569 (2001-09-01), None
patent: WO/02/26784 (2002-04-01), None
Krossoy B. et al., “The Putative Polymerase Sequence of Infectious Salmon Anemia Virus Suggests a New Genus within the Orthomyxovirdae” Journal of Virology, 73 (3) 2136-42, XP000986368, (1999).
Blake S. et al., “Genomic Relationships of the North American Isolate of Infectious Salmon Anemia Virus (ISAV) to the Norwegian Strain of ISAV”, Dis, Aquat. Org. 35 (2), 139-144, XP000984527, (1999).
Lovely J.E. et al. “First Identification of Infectious Salmon Virus Anaemia Virus in North America with Haemorrhagic Kidney Syndrome”, Diseases of Aquatic Organisms, 35 (2), 145-8, XP000984528, (1999).
Kibenge et al, “Antigenic Variation Among Isolates of Infectious Salmon Anaemia Virus Correlates with Genetic Variation of the Viral Haemagglutinin Gene”, Journal of General Virology, vol. 82, pp. 2869-2879, (2001).
Krossoy et al. “Cloning and Identification of the Infectious Salmon Anaemia Virus Haemagglutinin”, Journal of General Virology, vol. 82, pp. 1757-1765, (2001).
Rimstad et al, “Characterization of the Infectious Salmon Anemia Virus Genomic Segment that Enclosed the Putative Haemagglutinin”, Journal of Virology, vol. 75, No. 11, pp. 5352-5356, (2001).
Griffiths et al. Characterization of ISAV Proteins from Cell Culture, Diseases of Aquatic Organisms, vol. 45, pp. 19-24, (2001).
Mjaaland et al, “Genomic Characterization of the Virus Causing Infectious Salmon Anemia in Atlantic Salmon (Salmo salarL.): an Orthomyxo-Like Virus in Teleost”, Journal of Virology, vol. 71, No. 10, pp. 7681-7686, (1997).
Falk et al, Characterization of Infectious Salmon Anemia Virus an Orthomyzo-Like Virus Isolated from Atlantic Salmon (Salmo salarL.) Journal of Virology, vol. 71, No. 12, pp. 9016-9023, (1997).

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