Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2003-06-04
2010-06-22
Riley, Jezia (Department: 1637)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S024300, C536S025300, C435S006120
Reexamination Certificate
active
07741459
ABSTRACT:
The anchoring system generally comprises a solid support and a chemical linking moiety useful for ether formation with another chemical moiety on a nucleic acid molecule. The present invention further contemplates methods for anchoring a nucleic acid molecule to a solid support via a covalent linkage. The anchoring system of the present invention is useful inter alia in construction of nucleic acid arrays, to purify nucleic acid molecules and to anchor nucleic acid molecules so that they can be used as templates for in vitro transcription and/or translation experiments and to participate in amplification reactions. The present invention is particularly adaptable for use with microspheres and the preparation of microsphere suspension arrays and optical fiber arrays. The anchoring system permits the generation of an anchored oligonucleotide for use as a universal nucleic acid conjugation substrate for any nucleic acid molecule or population of nucleic acid molecules. The present invention further provides a kit useful for anchoring nucleic acid molecules or comprising nucleic acid molecules already anchored to a solid support.
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patent: 01/48244 (2001-07-01), None
Rogers, Y., et al., “Immobilization of Oligonucleotides Onto a Glass Support via Disulfide Bonds: A Method for Preparation of DNA Microarrays,”Anal Biochem., 266(1):23-30, Jan. 1, 1999.
Zhang, Y., et al., “Single-base Mutational Analysis of Cancer and Genetic Diseases Using Membrane Bound Modified Oligonucleotides,”Nucleic Acids Res., 19(14):3929-33, Jul. 25, 1991.
Poetter Karl Frederick
Toohey Brendan James
Genera Biosystems Limited
Riley Jezia
SEED IP Law Group PLLC
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