Nucleic acid analyzing method

Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...

Reexamination Certificate

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C204S455000

Reexamination Certificate

active

10432960

ABSTRACT:
To provide a method for analyzing a nucleic acid according to high throughput microcapillary electrophoresis during microchip electrophoresis under non-steady electric field, the method being capable of detecting polymorphism of a large number of genes at a high speed. The present invention is useful for the diagnosis and treatment of diseases such as detection of gene diseases and application to Taylor-made therapy.

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patent: 2002/0098504 (2002-07-01), Huang et al.
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patent: 11-148919 (1999-06-01), None
Derwent abstract of DE 4314755 A1.
Kim et al. (“Pulsed Filed Capillary Electrophoresis of Multikilobase length Nucleic Acids in Dilute Methyl Cellulose Solutions,” Anal. Chem. 1994, 66, 3081-3085).
Simpson, P.C. et al., PNAS, vol. 95, pp. 2256-2261 (1998).
Ueda, M. et al., Chromatography, vol. 21, No. 2, pp. 105-106 (2000).
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Bakajin, O. et al., Anal. Chem. vol. 73, p. 6053-6056 (2001).
Huang, L.R. et al., Nat. Biotech., vol. 20, p. 1048-1051 (2002).

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