Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-01-22
2009-06-09
Whisenant, Ethan (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C536S023100, C536S024300
Reexamination Certificate
active
07544473
ABSTRACT:
The present invention provides methods and compositions for tagging nucleic acid sequence fragments, e.g., a set of nucleic acid sequence fragments from a single genome, with one or more unique members of a collection of oligonucleotide tags, or sequence tokens, which, in turn, can be identified using a variety of readout platforms. As a general rule, a given sequence token is used once and only once in any tag sequence. In addition, the present invention also provides methods for using the sequence tokens to efficiently determine variations in nucleotide sequences in the associated nucleic acid sequence fragments.
REFERENCES:
patent: 5604097 (1997-02-01), Brenner
patent: 5635400 (1997-06-01), Brenner
patent: 5846719 (1998-12-01), Brenner et al.
patent: 5888737 (1999-03-01), DuBridge et al.
patent: 6136537 (2000-10-01), Macevicz
patent: 6897023 (2005-05-01), Fu et al.
patent: 7262030 (2007-08-01), Chen
patent: 2003/0044771 (2003-03-01), Anderson et al.
patent: 2007/0269870 (2007-11-01), Church et al.
patent: WO99/00519 (1999-01-01), None
Collins et al,A vision for the future of genomics research. Nature, 422: 835-847 (2003).
Gerry et al, Universal DNA microarray method for multiplex detection of low abundance point mutations. J. Mol. Biol., 292: 251-262 (1999).
Gunderson et al, A genome-wide scalable SNP genotyping assay using microarray technology. Nature Genetics, 37: 549-554 (2005).
Hardenbol et al, Highly multiplexed molecular inversion probe genotyping: over 10,000 targeted SNPs genotyped in a single tube assay. Genome Research, 15: 269-275 (2005).
Kennedy et al, Large-scale genotyping of complex DNA. Nature Biotechnology, 21: 1233-1237 (2003).
Margulies et al, Genome sequencing in microfabricated high-density picolitre reactors. Nature, 437: 376-380 (2005).
Shoemaker et al, Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy. Nature Genetics, 14: 450-456 (1996).
Stephens et al, A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer. Nature Genetics, 37: 590-592 (2005).
Syvanen. Accessing genetic variation: genotyping single nucleotide polymorphisms. Nature Reviews Genetics, 2: 930-942 (2002).
Till et al. High-throughput discovery of rare human nucleotide polymorphisms by ecotillin. Nucleic Acids Research, Aug. 7, 2006;34(13):e99.
Brenner et al. In vitro cloning of complex mixtures of DNA on microbeads: physical separation of differentially expressed cDNAs. Proceedings of the National Academy of Sciences, (2000), vol. 97, (4): 1665-70.
Griffiths, et al. Modern genetic analysis. W H Freeman and Company, 1999; Edited by Sara Tenney, Textbook ISBN 0-7167-3118-5 Text; Chapter 10. Retrieved from the internet:<URL:http://www.ncbi.nlm.nib.gov/books/bv.fcgi?rid=mga (Chapter 10-Fig 10.8).
Bozicevic Field & Francis LLP
Population Genetics Technologies Ltd.
Scherer David C.
Whisenant Ethan
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