Nucleic acid analog with amide linkage and method of making that

Details Nucleic acid analog with amide linkage and method of making that Nucleic acid analog with amide linkage and method of making that

1995-07-13

1997-06-10

Elliott, George C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 231, 536 253, 536 2531, 536 2532, 435 6, 935 76, 935 77, 935 78, C07H 1900, C12Q 168, C12N 1500

Patent

active

056376839

ABSTRACT:
The present invention relates to a nucleic acid analog having the formula: ##STR1## where R is a compound selected from a group consisting of hydrogen, a hydroxyl group, a hydrophilic group or a hydrophobic group,

REFERENCES:
Eghol m, et al., "Peptide Nucleic Acids (PNA), Oligonucleotide Analogues with an Achiral Peptide Backbone," J. Am. Chem. Soc., 114(5):1895-97 (1992).
Chur, et al., "Synthesis of a Carboxamide Linked T*T Dimer and its Incorporation in Oligonucleotides," Nucleic Acids Research, 21(22):5179-83 (1993).
Lebreton, et al., "Synthesis of Thymidine Dimer Derivatives Containing an Amide Linkage and Their Incorporation Into Oligodeoxyribonucleotides," Tetrahedron Letters, 34(40):6383-86 (1993).
De Mesmaeker, et al., "Novel Backbone Replacements for Oligonucleotides," in Carbohydrate Modifications in Antisense Research, 24-39, Yogesh Sanghui and P. Dan Cook, Eds. (1994).
De Mesmaeker, et al., "Amides as a New Type of Backbone Modification in Oligonucleotides," Angew. Chem. Int. Ed. Engl., 33(2):226-29 (1994).
Verheggen et al. "Synthesis and Antiherpes Virus Activity of 1,5-Anhydrohexitol Nucleosides" J. Med. Chem., vol. 36, pp. 2033-2040 1993.
Jois et al. "Synthesis and Antiviral Evaluation of Some Novel [1,2,4]Triazolo[4,3-b][1,2,4]triazole Nucleoside Analogs" J. Heterocyclic Chem., vol. 30, pp. 1289-1292 1993.
Neidlein et al. "Syntheses and Investigations of [Oxazolo[2,3-a]isoindol-9b(2H)-yl]phosphonates and phosphinates: a New Class of Heterocycles" Helv. Chim. Acta, vol. 76, pp. 2407-2417 1993.

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