Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1993-07-01
1997-08-12
Elliott, George C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
435 6, 435 71, 435 77, 435 772, 435 911, 435810, 436501, 5303871, 5303913, 5303915, 536 231, 536 241, 536 2431, 536 2432, 536 2433, 935 77, 935 78, C07K 1600
Patent
active
056567316
ABSTRACT:
In one aspect of this invention, various protein
ucleic acid hybrid probes are described which can be used to amplify the detectable signal in immunoassays. The protein moiety is capable of functioning either as an antibody or an antigen. The nucleic acid moiety serves as a signal amplifier. In another aspect, various methods of amplifying the detectable signal in immunoassays by use of the hybrid probes and related polynucleotide probes are disclosed.
REFERENCES:
patent: 4299916 (1981-11-01), Litman et al.
patent: 4563419 (1986-01-01), Ranki et al.
patent: 4626501 (1986-12-01), Landes
patent: 4687732 (1987-08-01), Ward et al.
patent: 4692509 (1987-09-01), Dattagupta
patent: 4737454 (1988-04-01), Dattagupta et al.
patent: 4749647 (1988-06-01), Thomas et al.
patent: 4766072 (1988-08-01), Jendrisak et al.
patent: 4828979 (1989-05-01), Klevan et al.
patent: 4868105 (1989-09-01), Urdea et al.
patent: 4873187 (1989-10-01), Taub
patent: 4882269 (1989-11-01), Schneider et al.
patent: 4910300 (1990-03-01), Urdea et al.
patent: 4925785 (1990-05-01), Wang et al.
patent: 4957858 (1990-09-01), Chu et al.
patent: 5124246 (1992-06-01), Urdea et al.
patent: 5175270 (1992-12-01), Nilsen et al.
patent: 5428132 (1995-06-01), Hirsch et al.
patent: 5571670 (1996-11-01), Urdea et al.
Dunn et al. (1983) J. Mol. Biol., vol. 166, pp. 477-535.
Czichos et al. (1989) Nuc. Acids Res., vol. 17, No. 4, pp. 1563-1572.
Fahrlander et al., "Amplifying DNA probe signals: a `Christmas tree` approach" Bio/Technology (1988) 6:1165-1168.
Ziemer et al., "Sequence of Hepatitis B virus DNA incorporated into the genome of human hepatoma cell line" Virology (1985) 53(3):885-892.
Chu et al., Nucleic Acids Research (1986) 14(14):5591-5603.
Syvanen et al., Nucleic Acids Research (1986) 14(12):5037-5048.
Syvanen et al., Nucleic Acids Research (1988) 16(23):11327-1133.
Blackburn Robert P.
Chiron Corporation
Dylan, Ph.D. Tyler
Elliott George C.
Goldman Kenneth M.
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