Nucleic acid amplification reaction apparatus

Details Nucleic acid amplification reaction apparatus Nucleic acid amplification reaction apparatus

1994-08-31

1998-02-24

Marschel, Ardin H.

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Means for analyzing liquid or solid sample

422 50, 422 62, 422 63, 422 67, 422 69, 422 81, 422 8205, 422 8208, 422 8209, 422129, 422131, 422132, 422134, 422138, 422149, 422159, 422187, 422188, 422189, 422196, 422197, 422198, 422209, 422236, 435 6, 435 911, 435 912, 435 915, 4352831, 4352851, 4352852, 4352871, 4352872, 4352873, 4352891, 4352901, 436501, 935 77, 935 78, 935 88, C12Q 168, C12M 140, C12P 1934

Patent

active

057209235

ABSTRACT:
Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample through a capillary tube loop passing through two thermostatted fluid baths. Another embodiment has the capillary tube routed alternatingly between two heat exchangers to that the sample makes only one pass through the tube. Other embodiments maintain the heat exchangers stationary and translate the samples between them. Still further embodiments maintain the samples stationary and either automatically translate or rotate the heat exchangers past the samples contained within the capillary tubes to perform the thermal cycles necessary for the amplification reaction.

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