Nuclease-resistant hydrophilic complex of polyriboinosinic-polyr

Details Nuclease-resistant hydrophilic complex of polyriboinosinic-polyr Nuclease-resistant hydrophilic complex of polyriboinosinic-polyr

1975-09-04

1977-05-17

Torrence, Dolph H.

Drug, bio-affecting and body treating compositions

Lymphokine

2601125R, 424177, 424180, 536 28, A61K 3700, A61K 4502, A61K 4504

Patent

active

040242412

ABSTRACT:
A nuclease-resistant hydrophilic complex of polyriboinosinic-polyribocytidylic acid, poly-l-lysine and carboxymethylcellulose, and injectable preparations thereof in a pharmaceutically acceptable aqueous carrier such as saline solution. When administered to a primate host, the complex is effective in inducing the synthesis in such host of antiviral levels of interferon.

REFERENCES:
patent: 2851453 (1958-09-01), Kennon
patent: 3066075 (1962-11-01), Deutsch
patent: 3952097 (1976-04-01), Levy
Matsuo et al., Bull. Chem. Soc. Japan, 39, 347-352 (1966).

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