Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-05-31
1996-10-22
Vogel, Nancy T.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
514 44, 514738, 568853, C07H 2100, A61K 31045, A61K 31715, C07C 3120
Patent
active
055678106
ABSTRACT:
Compounds, compositions and methods for inhibiting gene expression are disclosed. The compounds comprise oligonucleotide sequences of from about 9 to about 200 bases having a diol at either or both termini. Preferred diols are polyalkyleneglycols, preferably polyethyleneglycols. Pharmaceutical compositions comprising the compounds and a physiologically acceptable carrier and methods of inhibiting gene expression in mammals comprising administering such compounds are also provided. Methods for inhibiting nuclease cleavage of compounds are also provided.
REFERENCES:
patent: 4914210 (1990-04-01), Levenson et al.
Gura Science 270 575-577 (1995) Antisense has growing pains.
Hackh et al. (1937) Hackh's Chemical Dictionary, Second Ed. Blakiston's Son & Co., Inc. Philadelphia, PA p. 21.
Thuong et al. (1987) PNAS vol. 84: 5129-5133.
Cavanaugh, Jr. Paul F.
Hausheer Frederick H.
Moskwa Patricia S.
Oakes Fred T.
Weis Alexander L.
Brusca John S.
Davis William J.
DuPont Paul E.
Sterling Drug Inc.
Vogel Nancy T.
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