Multicellular living organisms and unmodified parts thereof and – Method of making a transgenic nonhuman animal – Via microinjection of a nucleus into an embryo – egg cell – or...
Reexamination Certificate
2003-07-31
2008-05-13
Crouch, Deborah (Department: 1632)
Multicellular living organisms and unmodified parts thereof and
Method of making a transgenic nonhuman animal
Via microinjection of a nucleus into an embryo, egg cell, or...
C800S017000
Reexamination Certificate
active
07371922
ABSTRACT:
Provided is a method for the production of transgenic animals, especially pigs, by the use of nuclear transfer from genetically modified or other embryonic stem cells to either enucleated oocytes which were matured in vivo or in vitro and activated or to enucleated zygotes.
REFERENCES:
patent: 4994384 (1991-02-01), Prather et al.
patent: 5057420 (1991-10-01), Massey
patent: 5523226 (1996-06-01), Wheeler
patent: 5994619 (1999-11-01), Stice et al.
patent: 6011197 (2000-01-01), Strelchenko et al.
patent: 6025540 (2000-02-01), Hansson
patent: 6080912 (2000-06-01), Bremel et al.
patent: 6156569 (2000-12-01), Ponce de Leon et al.
patent: 6193647 (2001-02-01), Beebe et al.
patent: 6258998 (2001-07-01), Damiani et al.
patent: 2003/0070186 (2003-04-01), Strelchenko
Chen et al. Theriogenology 52:195-212, 1999.
Denning et al. Reproduction 126:1-11, 2003.
Shim et al. Biol. Reprod. 57:1089-1095, 1997.
Kuhholzer et al. Mol Reprod Dev 56:145-148, 2000.
Sato et al. Human Cell 13(4):197-202.
Wilmut et al. Nature 385:810-813, Feb. 1997.
Wheeler et al. Reprod. Fertil. Dev. 6:563-568, 1994—IDS reference for 103 rejection.
Wakayama et al. Mice cloned from embryonic stem cells. Proc. Natl. Acad. Sci. (USA). Dec. 21, 1999. vol. 96, No. 26, pp. 14984-14989.
Tatham et al. Enucleation by Centrifugation of In Vitro-Matured Bovine Oocytes for Use in Nuclear Transfer. Bio. Reprod., vol. 53, pp. 1088-1094.
Allen et al. (1984). “In vitro Development of Porcine Embryos in Coculture with Endometrical Cell Monolayers or Culture Supernatants,”J. Anim. Sci. 59:1657-1661.
Amano et al. (2001) “Full-Term Development of Enucleated Mouse Oocytes Fused with Embryotic Stem Cells from Different Cell Lines,”Reproduction121:729-733, 2001.
Amano, et al. (2001) “Mouse Cloned from Embryonic Stem (ES) Cells Synchronized in Metaphase with Nocodazole,”J. Exp. Zoo. 289:139-145.
Archibong et al. (1989) “Development of Porcine Embryos From One- and Two-Cell Stages to Blastocysts in Culture Medium Supplemented with Porcine Oviductal Fluid,”Biol. Reprod. 41:1076-1083.
Balakier et al. (1993) “Experimentally Induced Parthenogenetic Activation of Human Oocytes,”Hum. Reprod. 8(5):740-743.
Barnes et al. (1993) “Influence of Recipient Oocyte Cell Cycle Stage on DNA Synthesis, Nuclear Envelope Breakdown, Chromosome Constitution, and Development in Nuclear Transplant Bovine Embryos,”Mol. Reprod. Dev. 36:33-41.
Bleck et al. (1998) “Production of Bovine Alpha-Lactalbumin in the Milk of Transgenic Pigs,”J. Anim. Sci.76:3072-3078.
Boston et al. (2001) “Short Communication: Effects of Increased Expression of Alpha-Lactalbumin in Transgenic Mice on Milk Yield and Pup Growth,”J. Dairy Sci.84:620-622.
Bradshaw et al. (1995) “UV Irradiation of Chromosomal DNA and its Effect upon MPF and Meiosis in Mammalian Oocytes,”Mol. Reprod. Dev.41:503-512.
Brem et al. (1985) “Production of Transgenic Mice, Rabbits and Pigs by Microinjection into Pronuclei,”Zuchthygiene20:251-252.
Campbell et al. (1994) “Improved Development to Blastocyst of Ovine Nuclear Transfer Embryos Reconstructed During the Presumptive S-phase of Enucleated Activated Oocytes,”Biol. Reprod.50:1385-1393.
Campbell et al. (1994) “Recent Advances on in vitro Culture and Cloning of Ungulate Embryos,” Proceedings of the 5th International Congr. on Genetics Applied to Livestock Production 20:180-187.
Campbell et al. (1997) “Totipotency or Multipotentiality of Cultured Cells: Applications and Progress,”Theriogenology47:63-72.
Campbell et al. (1996) “Sheep Cloned by Nuclear Transfer from a Cultured Cell Line,”Nature380:64-66.
Campbell et al. (1996) “Cell Cycle Co-Ordination in Embryo Cloning by Nuclear Transfer,”Rev. Reprod.1:40-46.
Chastant et al. (1996) “Quantitative Control of Gene Expression by Nucleocytoplasmic Interactions in Early Mouse Embryos: Consequence for Reprogammation by Nuclear Transfer,”Mol. Reprod. Dev.44:423-432.
Cheong et al. (1993) “Assessment of Cytoplasmic Effects on the Development of Mouse Embryonic Nuclei Transferred to Enucleated Zygotes,”Theriogenology39:451-461.
Cheong et al. (1992) “Development of Mouse Embryonic Nuclei Transferred to Enucleated Oocytes and Zygotes,”Jpn. J. Vet. Res.40:149-159.
Cheong et al. (1993) “Birth of Mice After Transplantation of Early Cell-Cycle-Stage Embryonic Nuclei into Enucleated Oocytes,”Biol. Reprod.48:958-963.
Cheong et al. (1994) “Relationship Between Nuclear Remodeling and Subsequent Development of Mouse Embryonic Nuclei Transferred to Enucleated Oocytes,”Mol. Reprod. Dev.37:138-145.
Cibelli et al. (1997) “Production of Germline Chimeric Bovine Fetuses From Transgenic Embryonic Stem Cells,”Theriogenology47:241 (Abstr.).
Collas et al. (1994) “Nuclear Transplantation by Microinjection of Inner Cell Mass and Granulosa Cell Nuclei,”Mol. Reprod. Dev.38:264-267.
Collas et al. (1989) “Electrical Activation of Mouse Oocytes,”Theriogenology32:835-844.
Collas et al. (1990) “Factors Affecting the Efficiency of Nuclear Transplantation in the Rabbit Embryo,”Biol. Reprod.43:877-884.
Collas et al. (1991) “Relationship Between Nuclear Remodeling and Development in Nuclear Transplant Rabbit Embryos,”Biol. Reprod.45:455-465.
Cuthbertson, K.S.R. (1983) “Parthenogenetic Activation of Mouse Oocytes in vitro with Ethanol and Benzyl Alcohol,”J. Exp. Zool.226:311-314.
Czolowska et al. (1984) “Behaviour of Thymocyte Nuclei in Nonactivated and Activated Mouse Oocytes,”J. Cell Sci.69:19-34, 1984.
Delhaise et al. (1995) “Nuclear Transplantation Using Bovine Primordial Germ Cells From Male Fetuses,”Reprod. Fertil. Dev.7:1217-1219.
Didion et al. (1990) “Parthenogenetic Activation of Mouse and Pig Oocytes Matured in vitro,”Theriogenology33:1165-1175.
Du et al. (1995) “Nuclear Transfer of Putative Rabbit Embryonic Stem Cells Leads to Normal Blastocyst Development,”J. Reprod. Fertil.104:219-223.
Du et al. (1995) “Beneficial Effect of Oocyte Activation Prior to and During Nuclear Transfer in Cattle Using in vitro Matured Oocytes 24 h of Age,”Reprod. Nutr. Dev.35:703-712.
Eberhardt et al. (1994) “Oviductal Fluid and Growth Factors Failed to Enhance Development of Porcine Embryos,”Theriogenology41:1163-1172.
First et al. (1992) “Use of in vitro Matured Oocytes 24 hr of Age in Bovine Nuclear Transfer,”Theriogenology37:211 (Abstr.).
Fulka et al. (1996) “Nuclear Transplantation in Mammals: Remodeling of Transplanted Nuclei Under the Influence of Maturation Promoting Factor,”BioEssays18:835-840.
Fulka et al. (1994) “Nuclear Transplantation in Mammals: The Role of Maturation Promoting Factor,”Reprod. in Domest. Anim.29:352-353.
Fulka et al. (1993) “Noninvasive Chemical Enucleation of Mouse Oocytes,”Mol. Reprod. Dev.34:427-430.
Gerfen et al. (1995) “Isolation of Embryonic Cell-lines from Porcine Blastocysts,”Anim. Biotechnology6:1-14.
Grocholova et al. (1997) “The Protein Phosphatase Inhibitor Okadaic Acid Inhibits Exit from Metaphase II in Parthenogenetically Activated Pig Oocytes,”J. Exp. Zool.277:49-56.
Hagen et al. (1991) “Response of Porcine Oocytes to Electrical and Chemical Activation During Maturation in vitro,”Mol. Reprod. Dev.28:70-73.
Hammer et al. (1985) “Production of Transgenic Rabbits, Sheep and Pigs by Microinjection,”Nature(Lond.) 315:680-683.
Howlett et al. (1987) “Nuclear Cytoplasmic Interactions Following Nuclear Transplantation in Mouse Embryos,”Development101:915-923.
Illmensee et al. (1981) “Nuclear Transplantation in Mus musculus: Developmental Potential of Nuclei from Preimplantation Embryos,”Cell23:9-18.
Kashiwazaki et al. (1992) “Production of Chimeric Pgis b
Wheeler Matthew B.
White Brett R.
Crouch Deborah
Greenlee Winner and Sullivan P.C.
The Board of Trustees of the University of Illinois
LandOfFree
Nuclear transfer with porcine embryonic stem cells does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nuclear transfer with porcine embryonic stem cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nuclear transfer with porcine embryonic stem cells will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3983080