Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1977-11-23
1979-06-26
Chan, Nicky
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424315, C07C14386
Patent
active
041592794
ABSTRACT:
Nuclear substituted 2-hydroxyphenylmethanesulfamic acids and their pharmaceutically acceptable salts wherein the phenyl nucleus is substituted with 2 to 4 nuclear substituents and which are useful saluretic-diuretics and anti-inflammatories are disclosed. The products may be prepared by reacting nuclear substituted salicylaldehydes with ammonium sulfamate to generate intermediate imines which are reduced to afford the compounds of this invention.
REFERENCES:
patent: 2662094 (1953-12-01), Kamlet
patent: 3794734 (1974-02-01), Cragoe, Jr. et al
Yamaguchi, Nippon Kagaku Zasshi, 89, 1099 (1968 (Chem. Abstract, 70, 96289v (1969)).
Cragoe, Jr. Edward J.
Smith Robert L.
Stokker Gerald E.
Chan Nicky
Merck & Co. , Inc.
Sudol, Jr. Michael C.
Westlake, Jr. Harry E.
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