Nuclear protein

Details Nuclear protein Nuclear protein

2006-12-19

2006-12-19

Minnifield, Nita (Department: 1645)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C435S005000, C435S069100, C435S069700, C435S320100, C435S325000, C435S006120, C536S023200, C530S300000, C530S388100

Reexamination Certificate

active

07151162

ABSTRACT:
An isolated Shoca polypeptide comprising:(i) the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4; or(ii) a variant thereof which is capable of interacting with a polypeptide of the wnt signalling pathway; or(iii) a fragment of (i) or (ii) which is capable of interacting with a polypeptide of the wnt signalling pathway, a polypeptide encoding said polypeptide, a method for identifying a modulator of the wnt signalling pathway utilising said polypeptide or polynucleotide and methods of diagnosing and treating cancer.

REFERENCES:
patent: 6239161 (2001-05-01), Tang et al.
patent: WO 01/53455 (2001-07-01), None
patent: WO 01/54733 (2001-08-01), None
patent: WO 01/74851 (2001-10-01), None
Acession No. S67766.
Nature Genetics, 1999, 21:440-443).
Journal of Cell Science 2001; 114, 2043-2053.
Alberts et al. (Molecular Biology of the Cell, 3rd edition, 1994, p. 465).
Campbell, monoclonal antibody technology 1984, Chapter 1, p. 29.
EMBL database Accession No. BB599521, XP-002240709 (2003).
EMBL database Accession No. AC021028, XP-002240710 (2002).
Brennan et al. “Wnt proteins in mammary development and cancer” J. Mammary Gland Biol. Neopl. 9:119-131 (2004).
Doucas et al. “Changes in the wnt signalling pathway in gastrointestinal cancers and their prognostic significance” Eur. J. Cancer 41:365-279 (2005).
Li et al. “CTNNB1 mutations and overexpression of wnt/β-catenin target genes in WT1-mutant Wilms' tumors” Am. J. Pathol. 165:1943-1953 (2004).
Mazieres et al. “Wnt signaling in lung cancer” Cancer Lett. 222:1-10 (2005).
Waterman “Lymphoid enhancer factor/T cell factor expression in colorectal cancer” Cancer Metastasis Rev. 23:41-52 (2004).
Int'l Preliminary Examination Report dated Apr. 4, 2004.
Int'l Search Report dated May 12, 2003.
Choi et al. “Lad, an adapter protein interacting with the SH2 domain of p56ICR, is required for T cell activation” J. Immunol. 163:5242-5249 (1999).
Peifer et al. “Wnt signaling on oncogenesis and embryogenesis—a look outside the nucleus” Science 287:1606-1609 (2000).
Polakis “Wnt signaling and cancer” Genes & Development 14:1837-1851 (2000).
Sawyer “Src homology-2 domains: Structure, mechanisms, and drug discovery” Biopolymers 47:243-261 (1998).
Spurkland et al. “Molecular cloning of a T cell-specific adapter protein (TSAd) containing an Src homology (SH) 2 domain and putative SH3 and phosphotyrosine binding sites” J. Biol. Chem. 273:4539-4546 (1998).

Affiliated with

Also associated with

Rating

Nuclear protein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nuclear protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nuclear protein will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3694228