Nuclear matrix proteins

Details Nuclear matrix proteins Nuclear matrix proteins

1999-02-23

2000-02-29

Cochrane Carlson, Karen

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

5303871, C07K 1618, C12Q 100, G01N 3353

Patent

active

060307935

ABSTRACT:
Nuclear matrix proteins (NMP) which are characterized by a defined expression in tissue are provided. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a cell and treating cell proliferative disorders associated with the NMP. Also provided are substantially purified polypeptides and nucleotide sequences encoding the NMPs of the invention.

REFERENCES:
patent: 4882268 (1989-11-01), Perman et al.
patent: 5874539 (1999-02-01), Coffey et al.
Thomas E. Miller et al., "Detection of Nuclear Matrix Proteins in Serum from Cancer Patients," Cancer Research, 52, pp. 422-427, Jan. 15, 1992.
Robert H. Getzenberg et al., "Modifications of the Intermediate Filament and Nuclear Matrix Networks by the Extracellular Matrix," Biochemical and Biophysical Research Communications, vol. 179, No. 1, 1991, pp. 340-344.
James F. Cupo, "Electrophoretic analysis of nuclear matrix proteins and the potential clinical applications," Journal of Chromatography, 569 (1991) pp. 389-406.
Robert H. Getzenberg et al., "Identification of Nuclear Matrix Proteins in the Cancer and Normal Rat Prostate," Cancer Research, 51:6514-6520, Dec. 15, 1991.

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