Nuclear magnetic resonance imaging agent comprising a di-aldehyd

Details Nuclear magnetic resonance imaging agent comprising a di-aldehyd Nuclear magnetic resonance imaging agent comprising a di-aldehyd

1992-07-08

1993-12-21

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

514 54, 514 57, 514 59, 514836, 436173, 1286534, 534 16, 536104, 536105, G01N 2408, A61K 31715, C08B 3508, C07H 2300

Patent

active

052719294

ABSTRACT:
There is disclosed a nuclear magnetic resonance imaging agent comprising a complex compound composed of (a) a dialdehyde-saccharide having a molecular weight of from 500 to 10,000, at least one of the constituent monosaccharides of which is oxidation-cleaved, (b) at least one complexing agent which is chemically coupled to an aldehyde group of the dialdehyde-saccharide and (c) a paramagnetic metal ion which is chemically coupled to the complexing agent.

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Ogan, Marc D., et al., Investigative Radiology, vol. 22, 665-671 (Aug. 1987).
Wang, S., et al., Radiology 1990: 175:483-488.

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