Combinatorial chemistry technology: method – library – apparatus – Method specially adapted for identifying a library member – Identifying a library member by means of a tag – label – or...
Reexamination Certificate
2011-06-21
2011-06-21
Steele, Amber D. (Department: 1639)
Combinatorial chemistry technology: method, library, apparatus
Method specially adapted for identifying a library member
Identifying a library member by means of a tag, label, or...
C506S006000, C506S009000, C506S012000, C435S007100
Reexamination Certificate
active
07964534
ABSTRACT:
The invention provides a method for identifying a ligand that binds to a macromolecular target. The methods involve (a) attaching an antenna moiety to a first ligand, wherein the ligand binds specifically to a macromolecular target; (b) providing a sample comprising the macromolecular target, the first ligand and a candidate second ligand under conditions wherein the first ligand and the macromolecular target form a bound complex; (c) detecting a subset of magnetization transfer signals between the antenna moiety of the first ligand and the second candidate ligand, wherein the signals are obtained from an isotope edited NOESY spectrum of the sample; thereby determining that the two ligands are proximal in a bound complex, and identifying a second ligand that binds to the macromolecular target.
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Kelly Mark
Lee Min S.
Qin Yong
Sem Daniel S.
Villar Hugo
McDermott Will & Emery LLC
Steele Amber D.
Triad Liquidating Company, LLC
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