Nuclear factors associates with transcriptional regulation

Details Nuclear factors associates with transcriptional regulation Nuclear factors associates with transcriptional regulation

1995-04-06

1998-09-08

Degen, Nancy

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 241, C12Q 168, C12N 1511

Patent

active

058043748

ABSTRACT:
Constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are described. The factors were identified and isolated by an improved assay for protein-DNA binding. Genes encoding factors which positively regulate transcription can be isolated and employed to enhance transription of Ig genes. In particular, NF-kB, the gene encoding NF-kB, IkB and the gene encoding IkB and uses therefor.

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