Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-06-05
2000-11-21
Schwartzman, Robert A.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 71, 435 29, C12Q 102, C12Q 168, G01N 3353
Patent
active
061500909
ABSTRACT:
Constitutive and tissue-specific protein factors which bind to transcriptional regulatory elements of Ig genes (promoter and enhancer) are described. The factors were identified and isolated by an improved assay for protein-DNA binding. Genes encoding factors which positively regulate transcription can be isolated and employed to enhance transription of Ig genes. In particular, NF-kB, the gene encoding NF-kB, IkB and the gene encoding IkB and uses therefor.
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Baeuerle Patrick A.
Baldwin, Jr. Albert S.
Baltimore David
Clerc Roger G.
Corcoran Lynn M.
Clauss Isabelle M.
Massachusetts Institute of Technology
President and Fellows of Harvard College
Schwartzman Robert A.
Vincent Matthew P.
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