Nuclear factor κB inducing factor

Details Nuclear factor κB inducing factor Nuclear factor κB inducing factor

2006-05-09

2006-05-09

Epps-Ford, Janet L. (Department: 1633)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C536S023100, C536S023500, C435S069100, C435S320100

Reexamination Certificate

active

07041497

ABSTRACT:
The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFκB induction in a patient, methods and compositions for lowering NFκB induction in a patient, methods for inhibiting inflammation, and methods for manufacture of a medicament intended for the treatment and/or prevention of an NFκB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.

REFERENCES:
patent: 6132964 (2000-10-01), Bandman et al.
patent: 6518029 (2003-02-01), Bandman et al.
patent: WO99/58675 (1999-11-01), None
patent: WO01/31030 (2001-05-01), None
patent: WO01/53312 (2001-07-01), None
patent: WO01/77389 (2001-10-01), None
patent: WO01/94629 (2001-12-01), None
Sugano et al. Online EMBL Database; “Homo sapienscDNA FLJ20177, Clone COL09966, highly similar to Y08136 H,” Accession No. AK000184, (Feb. 22, 2000).
Chatterjee,Arterioscler. Thromb. Vasc. Biol.18:1523-1533 (1998).
Dias Neto et al.,Proc. Natl. Acad. Sci. USA, 97(7) 3491-3496 (2000).
Gius, et al.,Toxicology Letters, 106:93-106 (1999).
Khaled et al.,Clin. Immunol. Immunopathol., 83(3):254-263 (1997).
Lentsch and Ward,Clin. Chem. Lab. Med., 37(3):205-208 (1999).
Levade and Jaffrezou,Biochim. Biophys. Acta1438:1-17 (1999).
Li and Gaynor,Gene Expr., 7(4-6):233-245 (1999).
Mallat et al.,Circulation, 99:348-353 (1999).
Morrissey and Klahr,Seminars in Nephrology, 18(6):603-611 (1998).
Mukhopadhyay et al.,Oncogene, 11(5):999-1003 (1995).
Murakami et al.,Virology, 206:1066-1074 (1995).
Piette et al.,Biol. Chem., 378:1237-1245 (1997).
Schissel et al.,J. Biol. Chem., 271(31):18431-18436 (1996).
Schuchman et al.,J. Biol. Chem.266(13):8531-8539 (1991).
Sugano et al., Online EMBL Database; “Homo sapienscDNA FLJ20177 fis, clone COL09966, highly similar to Y08136 H”, Accession No.: AK000184, (Feb. 22, 2000).
Tabas et al.,J. Biol. Chem.268(27): 20419-20432 (1993).
Visconti et al.,Oncogene, 15(16) 1987-1994 (1997).

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