Nuclear factor κB inducing factor

Details Nuclear factor κB inducing factor Nuclear factor κB inducing factor

2011-07-05

2011-07-05

Epps-Smith, Janet L. (Department: 1633)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C536S023100, C536S023500, C435S069100, C435S320100

Reexamination Certificate

active

07972844

ABSTRACT:
The present invention is directed to nuclear factor κB (NFκB)-inducing factor polypeptides (NFIF polypeptides) which are capable of inducing NFκB. The present invention includes within its scope NFIF polypeptides, including NFIF-14b and NFIF-7a, DNA, including cDNA, encoding these polypeptides, and expression vectors capable of expressing NFIF polypeptides. Also included are methods and compositions for increasing NFκB induction in a patient, methods and compositions for lowering NFκB induction in a patient, methods for inhibiting inflammation, and methods for manufacture of a medicament intended for the treatment and/or prevention of an NFκB-regulated inflammatory response. In addition, methods for determining whether a test compound inhibits or enhances the activity of NFIF polypeptides are provided.

REFERENCES:
patent: 6132964 (2000-10-01), Bandman et al.
patent: 6518029 (2003-02-01), Bandman et al.
patent: WO 99/58675 (1999-11-01), None
patent: WO 00/00599 (2000-01-01), None
patent: WO 01/31030 (2001-05-01), None
patent: WO 01/53312 (2001-07-01), None
patent: WO 01/77389 (2001-10-01), None
patent: WO 01/94629 (2001-12-01), None
Palu et al. Journal of Biotechnology, vol. 68, 1999, pp. 1-13.
Pahl., H.L., Activtors and target genes of Rel/NF-kappa B transcription Factors, Oncogene. vol. 18, No. 49, Nov. 22, 1999, pp. 6853-6866.
Chatterjee et al., Sphingolipids in atherosclerosis and vascular biology, Arterioscler. Thromb. Vasc. Biol. vol. 18, 1998, pp. 1523-1533.
Dias Neto et al., Shotgun sequencing of the human transcriptome with ORF expressed sequence tags, Proc. Natl. Acad. Sci. USA vol. 97 (7) 2000, pp. 3491-3496.
Gius et al., Intracellular oxidation/reduction status in the regulation of transcription factors NF-B and AP-1, Toxicology Letters, vol. 106, 1999, pp. 93-106.
Khaled et al., Inhibition of the p50 (NFkB1) Subunit of NF-kB by Phosphorothioate-Modified Antisense Oligodeoxynucleotides Reduces NF-kB Expression and Immunoglobulin Synthesis in Murine B Cells , Clin. Immunol. Immunopathol. vol. 83(3) 1997, pp. 254-263.
Lentsch et al., Activation and regulation of NFkappaB during acute inflammation., Clin. Chem. Lab. Med., vol. 37, No. 3, 1999, pp. 205-208.
Levade et al., Signalling sphingomyelinases: which, where, how and why, Biochimica et Biophysica Acta vol. 1438, 1999, pp. 1-17.
Li et al., Regulation of NF-kappaB by the HTLV-1 Tax protein., Gene Expr. vol. 7, No. 4-6, 1999, pp. 233-245.
Mallat e al., Shed Membrane Microparticles With Procoagulant Potential in Human Atherosclerotic Plaques , Circulation, vol. 99, 1999, pp. 348-353.
Morrissey et al., Transcription factor NF-kappaB regulation of renal fibrosis during ureteral obstruction, Seminars and Nephrology, vol. 18, No. 6, 1998, pp. 603-611.
Mukhopadhyay et al., Altered expression of the p50 subunit of the NF-kappa B transcription factor complex in non-small cell lung carcinoma, Oncogene, vol. 11, No. 5, 1995, pp. 999.1003.
Murakami et al., HTLV-1 Tax Enhances NF-kB2 Expression and Binds to the Products p52 and p100, but Does Not Suppress the Inhibitory Function of p. 100 , Virology, vol. 206, 1995, pp. 1066-1074.
Piette et al., Multiple redox regulation in NF-kappaB transcription factor activation, Biol. Chem., vol. 378, 1997, pp. 1237-1245.
Schissel et al., Zn2-stimulated Sphingomyelinase Is Secreted by Many Cell Types and Is a Product of the Acid Sphingomyelinase Gene , J. Biol. Chem., vol. 271, No. 31, 1996, pp. 18431-18436.
Schuchman et al., Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs , J. Biol. Chem., vol. 266, No. 13 1991, pp. 8531-8539.
Sugano et al.,Homo sapienscDNA FLJ20177, Clone COL09966, highly similar to Y08136 H, Accession No. AK00184, Feb. 22, 2000.
Tabas et al., Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation , J. Biol. Chem. vol. 268, No. 27, 1993, pp. 20419-20432.
Visconti et al., Expression of the neoplastic phenotype by human thyroid carcinoma cell lines requires NFkappaB p65 protein expression. Oncogene, vol. 15, No. 16, 1997, pp. 1987-1994.

Affiliated with

Also associated with

Rating

Nuclear factor κB inducing factor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nuclear factor κB inducing factor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nuclear factor κB inducing factor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2699165