Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1988-07-15
1991-06-25
Ford, John M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530326, A61K 3702, C07K 708
Patent
active
050266853
ABSTRACT:
Human Neuropeptide Y(NPY) has the formula: H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala- Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr- Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH.sub.2. Porcine and rat NPY have the same sequence except for Leu instead of Met in the 17-position. Porcine PYY is homologous having 11 different residues. NPY analogs wherein the N-terminus is shortened and which may contain one or more specific subsitutions for the naturally occurring residues, or pharmaceutically acceptable salts thereof, dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals, including humans, to substantially lower blood pressure over an extended period of time or to counteract hypertension.
REFERENCES:
patent: 4490364 (1964-12-01), Rivier et al.
patent: 4728726 (1988-03-01), Rivier et al.
Chang et al., "Specific [.sup.3 H]propionyl-neuropeptide Y (NPY) binding in rabbit aortic membranes: . . . ," Biochem. and Biophys. Res. Commun., 151: No. 3, pp. 1213-1219, Mar. 30, 1988.
Tatemoto, K., "Neuropeptide Y: Complete amino acid sequence of the brain peptide," Proc. Natl. Acad. Sci. U.S.A., 79: pp. 5485-5489, Sep. 1982.
Yamamoto et al., "Synthesis of Hexatriacontapeptide Amide Corresponding to the Proposed Structure of Neuropeptide Y (NPY)," Peptide Chemistry 1984, N. Izumiya (Ed.), Protein Research Foundation, Osaka (1985), pp. 317-322.
Solomon, T. E., "Pancreatic Polypeptide, Peptide YY, and Neuropeptide Y Family of Regulatory Peptides," Gastroenterology, 88: pp. 838-841, 1985.
Boublik Jaroslav H.
Brown Marvin R.
Rivier Jean E. F.
Scott Neal A.
Ford John M.
The Reagents of The University of California
The Salk Institute for Biological Studies
LandOfFree
NPY peptide analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with NPY peptide analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and NPY peptide analogs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1039927