Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1992-05-12
1994-07-12
Lee, Lester L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 12, 530324, 530326, A61K 3702, C07K 708, C07K 710
Patent
active
053288998
ABSTRACT:
Human Neuropeptide Y (NPY) has the formula: H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro- Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile- Thr-Arg-Gln-Arg -Tyr-NH.sub.2. Porcine and rat NPY have the same sequence except for Leu instead of Met in the 17-position. Porcine PYY is homologous having 11 different residues. NPY analogs and N-terminally-shortened fragments, e.g. NPY(18-36), which contain one or more specific D-isomer substitutions for the naturally occurring residues (as well as pharmaceutically acceptable salts thereof), dispersed in a pharmaceutically acceptable liquid or solid carrier, can be administered to mammals, including humans, to substantially lower blood pressure over an extended period of time or to counteract hypertension.
REFERENCES:
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patent: 4764504 (1988-08-01), Johnson et al.
patent: 5026685 (1991-06-01), Boublik et al.
Rioux, F. et al., Peptides, 7(1):27-31, 1986.
Boublik, et al., "Synthesis and Hypertensive Activity of Neuropeptide Y Fragments and Analogs with Modified N-or C-Termini . . . " J. Med. Chem. 32: 597-601, 1989.
Boublik et al., "Neuropeptide .sup.18-36 -An NPY Fragment With Hypotensive Action in Vivo", Proc. 11th A.P.S., Ed. J. Rivier & G. Marshall 1990 pp. 317-318.
Boublik, et al., "Neuropeptide Y and neuropeptide Y.sub.8-36 : structural and biological characterization," Int. J. Peptide Protein Research, 33:11-15 (1989).
Scott, et al., "Distinction of NPY receptors in vitro and in vivo II. Differential effects of NPY and NPY-(18-36)," J. Med. Chem., 35(15):H174-H180 (1990).
Boublik Jaroslav H.
Brown Marvin R.
Rivier Jean E. F.
Scott Neal A.
Lee Lester L.
The Regents of the University of California
The Salk Institute for Biological Studies
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