NPC1L1 (NPC3) and methods of identifying ligands thereof

Details NPC1L1 (NPC3) and methods of identifying ligands thereof NPC1L1 (NPC3) and methods of identifying ligands thereof

2011-03-08

2011-03-08

Haq, Shafiqul (Department: 1641)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007930, C436S544000, C548S953000

Reexamination Certificate

active

07901893

ABSTRACT:
The present invention provides human, rat and mouse NPCIL1 polypeptides and polynucleotides encoding the polypeptides. Methods for detecting ligands which bind to NPC1L1 and block intestinal cholesterol absorption are provided. Also included is a method of identifying ligands which bind to NPCILI using membranes derived from brush border membrane preparations. Compounds that bind to NPCILI can be used for inhibiting intestinal cholesterol absorption in a subject.

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