NP95: methods of assaying for cell cycle modulators

Details NP95: methods of assaying for cell cycle modulators NP95: methods of assaying for cell cycle modulators

2006-08-15

2006-08-15

Huff, Sheela J. (Department: 1643)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007100, C435S007200, C530S350000, C514S012200, C536S023100, C536S023500

Reexamination Certificate

active

07090990

ABSTRACT:
The present invention relates to regulation of cellular proliferation. More particularly, the present invention is directed to nucleic acids encoding NP95, which is involved in modulation of cell cycle arrest. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions, antibodies, peptides, cyclic peptides, nucleic acids, RNAi, antisense nucleic acids, and ribozymes, that modulate cell cycle arrest via modulation of NP95; as well as to the use of expression profiles and compositions in diagnosis and therapy related to cell cycle regulation and modulation of cellular proliferation, e.g., for treatment of cancer and other diseases of cellular proliferation.

REFERENCES:
Stein and Young, Science vol. 261 p. 1004 (1993).
Skolnick et al TIBTECH vol. 18 p. 34 (2000).
Citterio et al Molecular and Cellular Biology vol. 24 p. 2526 (2004).
Fujimori, A. et al “Cloning anf Mapping ofNp95Gene Which Encodes a Novel Nuclear Protein Associated with Cell Proliferation,”Mammalian Genome1998, pp. 1032-1035, vol. 9.
Miura, M. et al. “Dynamic Changes in Subnuclear NP95 Location During the Cell Cycle and Its Spatial Relationship with DNA Replication Foci,”Exper. Cell Res. 2001, pp. 202-208, vol. 263.
Uemura, T. et al. “Temporal and Spatial Localization of Novel Nuclear Protein NP95 in Mitotic and Meiotic Cells,”Cell Structure&Function2000, pp. 149-159, vol. 25.

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