Nozzle pore configuration for intrapulmonary delivery of...

Details Nozzle pore configuration for intrapulmonary delivery of... Nozzle pore configuration for intrapulmonary delivery of...

2011-06-14

2011-06-14

Yu, Justine R (Department: 3771)

Surgery

Liquid medicament atomizer or sprayer

C128S200240

Reexamination Certificate

active

07958887

ABSTRACT:
The present invention describes the configuration of a porous sheet for improving the efficiency for generating an aerosol from a liquid formulation. This aerosolized liquid formulation can be used for intrapulmonary delivery of pharmaceutically active drugs and diagnostic agents when said invention is used in conjunction with the appropriate device. The individual pores in each array (defined as the rows and columns of pores for example in a rectangular array) are generated such that there is a discrete or continuous variation in the pore size within the plurality of pores on the sheet. The drug is subsequently aerosolized by forcing the liquid formulation through the pores on the sheet. The resulting aerosol will contain a controlled range of particle sizes defined by the properties of the porous sheet and the liquid formulation.

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