Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2005-11-03
2009-10-27
Lewis, Patrick T (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S024000, C514S025000, C514S028000, C536S004100, C536S013000
Reexamination Certificate
active
07608594
ABSTRACT:
Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present invention are useful as heat shock protein 90 inhibitors, and may be used as anticancer and neuroprotective agents.
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Synthesis of Mono- and Dihydroxylated Furanoses, Pyranoses, and an Oxepanose for the Preparation of Natural Product Analogue Libraries; Xiao Ming Yu, et al.,J. Org. Chem. 2005, 70, 5599-5605.
Hsp90 Inhibitors Identified from a Library of Novobiocin Analogues; Xiao Ming Yu, et al.,J. Am. Chem. Soc. 2005, 127, 12778-12779.
Blagg Brian S.
Neckers Len
Yu Xiao Ming
Lewis Patrick T
Merchant & Gould
University of Kansas
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