Novel vitamin D.sub.3 derivatives and process for producing the

Details Novel vitamin D.sub.3 derivatives and process for producing the Novel vitamin D.sub.3 derivatives and process for producing the

1983-02-03

1985-05-14

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

204159, C07J 900

Patent

active

045171254

ABSTRACT:
There are disclosed 6,19-epidioxyvitamin D.sub.3 derivatives which are represented by the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each a hydrogen atom or a hydroxyl group; when R.sub.1 is a hydrogen atom, R.sub.2 represents a hydroxyl group and R.sub.3 is a hydrogen atom or a hydroxyl group; when both R.sub.1 and R.sub.2 represent a hydroxyl group, R.sub.3 is a hydrogen atom or a hydroxyl group; and when R.sub.1 is a hydroxyl group and R.sub.2 is a hydrogen atom, R.sub.3 represents a hydroxyl group. The compounds are highly capable of inducing differentiation of human myeloid leukemia cells with minimum effects on calcium metabolism and are useful as an agent to treat leukemia.

REFERENCES:
Chemical Abstracts 90 133429b (1979).
Chemical Abstracts 83 53688a (1975).
Chemical Abstracts 88 69462m (1978).
Proc. Natl. Acad. Sci. (USA) 75 (3), 1374-1378 (1978).

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