Novel vectors and method for controlling interferon expression

Details Novel vectors and method for controlling interferon expression Novel vectors and method for controlling interferon expression

1982-07-12

1986-04-15

Tanenholtz, Alvin E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

4351723, 435253, 435317, 435811, 935 29, 935 41, 935 45, 935 60, C12P 2102, C12N 1500, C12N 120, C12N 100

Patent

active

045828008

ABSTRACT:
Improved vectors and methods for regulating the expression in bacteria of a eucaryotic anti-viral protein, such as mature human immune interferon, the gene for which has been cloned onto a bacterial plasmid, is disclosed. The improved vectors incorporate and method utilizes transcriptional regulatory elements derived from bacteriophage lambda and ribosome binding sites either derived from bacteriophage lambda and/or synthesized chemically.

REFERENCES:
Derynck et al., Nature, vol. 287, pp. 193-197, Sep. 18, 1980.
Taniguchi et al., PNAS USA, vol. 77, pp. 5230-5233, Sep. 1980.
Guarente et al., Science, vol. 209, pp. 1428-1430, Sep. 19, 1980.
Gray et al., Nature, vol. 295, pp. 503-508, Feb. 11, 1982.

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