Novel use of benzodiazepine antagonist

Details Novel use of benzodiazepine antagonist Novel use of benzodiazepine antagonist

1985-08-13

1987-05-19

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

A61U 3155

Patent

active

046669035

ABSTRACT:
Benzodiazepine antagonists are used to regenerate the sensitivity response to and prevent tolerance of benzodiazepine which otherwise develops during chronic benzodiazepine exposure. The administration of a plurality of time spaced doses of the antagonist also prevents benzodiazepine withdrawal symptoms. The preferred benzodiazepine antagonist is flumazepil.

REFERENCES:
Chem. Abst. 97-138502(Z), 104,176(F) & 174930(W), (1982).
Sandra E. File, "Recovery from Lorazepam Tolerance and the Effects of a Benzodiazepine Antagonist (RO 15-1788) on the Development of Tolerance," Psychopharmacology (1982) 77:284-288.
Scott E. Lukas, Roland R. Griffiths, "Precipitated Withdrawal by a Benzodiazepine Receptor Antagonist (RO 15-1788) After 7 Days of Diazepam", Science, vol. 217, 17 Sep. 1982.
L. F. McNicholas and W. R. Martin, "The Effect of a Benzodiazepine Antagonist, RO15-1788, In Diazepam Dependent Rats," Life Sciences, vol. 31, pp. 731-737.
R. J. Lamb and R. R. Griffiths, "Effects of Repeated Ro 15-1788 Administration in Benzodiazepine-Dependent Baboons", European Journal of Pharmacology, vol. 110, No. 2, pp. 257-261.

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