Novel triazafluoranthene compound and processes for preparing th

Details Novel triazafluoranthene compound and processes for preparing th Novel triazafluoranthene compound and processes for preparing th

1980-12-10

1983-01-04

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544247, A61K 31505, C07D47116

Patent

active

043672302

ABSTRACT:
A triazafluoranthene compound of the formula: ##STR1## wherein R.sup.1 is hydrogen, phenyl, cycloalkyl having 3 to 6 carbon atom, (lower alkoxy)carbonyl, lower alkoxy or (lower alkyl)carbonyl, R.sup.2 is hydrogen or lower alkyl, R.sup.3 is hydrogen, phenyl, (lower alkoxy)carbonyl, lower alkoxy, di(lower alkyl)amino, (tetrahydropyran-2-yl)oxy, hydroxy or carboxyl, A is single bond, alkylene having one to 5 carbon atoms or alkenylene having 2 to 5 carbon atoms, and B is single bond or alkylene having one to 5 carbon atoms. Methods of preparing the compound (I) are disclosed. The compound (I) and a pharmaceutically acceptable acid addition salt thereof have a potent anti-anoxic activity.

REFERENCES:
patent: 4190657 (1980-02-01), Koletar et al.
patent: 4218453 (1980-08-01), Hannart
patent: 4277476 (1981-07-01), DuPont et al.
McOmie, Protective Groups in Organic Chemistry, Plenum Press, London and New York, (1973), pp. 62-63, 104-106 relied upon.
Laronze et al., Bull. Soc. Chim. France, 1977, No. 11-12, pp. 1207-1214.
Ordzhonikidze, S., Chemical Abstracts, vol. 84, 31133j, (1976).

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