Novel transient acyl derivatives of phenylbutazone

Details Novel transient acyl derivatives of phenylbutazone Novel transient acyl derivatives of phenylbutazone

1976-03-08

1977-07-19

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260270E, 2602955A, 260310A, 424263, 424270, 424273, C07D23106

Patent

active

040368459

ABSTRACT:
There is provided, novel, transient, pro-drug forms of phenylbutazone and oxyphenbutazone having the following formulas wherein the terms R, R.sub.2, R.sub.4, R.sub.5, X and Y are defined infra: ##STR1## The above-identified compounds exhibit anti-inflammatory activity in warm-blooded animals. Upon administration to warm-blooded animals, these compounds pass through the gastrointestinal tract and cleave in the bloodstream, thus releasing phenylbutazone or oxyphenbutazone in an anti-inflammatory effective amount at their therapeutic site or sites of activity.

REFERENCES:
patent: 3803120 (1974-04-01), Felix et al.
Burger, Medicinal Chemistry, Third Edition, Part II, Wiley-Interscience p. 959.

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