Novel thioamide derivatives containing a pyridazine group

Details Novel thioamide derivatives containing a pyridazine group Novel thioamide derivatives containing a pyridazine group

1979-08-06

1980-12-30

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

424250, 544224, C07D23708, C07D23714, C07D23718, A61K 3150

Patent

active

042425123

ABSTRACT:
Novel pyridazine-containing thioamide derivatives of the formula ##STR1## wherein R.sub.1 is ##STR2## wherein A is hydrogen, methyl, phenyl or mercapto, and B is hydrogen or phenyl; R.sub.2 is hydrogen or methyl; R.sub.3 is hydrogen, methyl or phenyl; R.sub.4 is hydrogen or methyl; and n is zero or 1. The derivatives have outstanding gastric antisecretory activity.

REFERENCES:
patent: 3624085 (1971-11-01), Malen et al.
patent: 3657243 (1972-04-01), Quintilla
patent: 3686190 (1972-08-01), Malen et al.
patent: 3825547 (1974-07-01), Loev

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