Novel thiazolidin-4-one derivatives and acid addition salts ther

Details Novel thiazolidin-4-one derivatives and acid addition salts ther Novel thiazolidin-4-one derivatives and acid addition salts ther

1987-07-17

1989-07-18

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546280, C07D21304, A61K 3144

Patent

active

048494348

ABSTRACT:
A novel 2-pyridylthiazolidin-4-one derivative represented by the general formula ##STR1## wherein Ar denotes an aryl group unsubstituted or substituted with a halogen atom or with a lower alkoxy group; X denotes a straight-chain or branched-chain lower alkylene group or a single bond; R denotes a hydrogen atom, lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, acyloxy, di(lower alkyl) amino, hydroxyl or aryl group, or denotes an aryl group substituted with a lower alkoxy group; and Py denotes a pyridyl group, and the acid addition salt thereof, which have an excellent platelet activating factor antagonsm.

REFERENCES:
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J. Indian. Chem. Soc., vol. L III, 1976, pp. 595-597.
J. Indian. Chem. Soc., vol. L V, 1978, pp. 424-426.
J. Biol. Chem., 255, 5514-5516 (1980).

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