Novel tetrahydropyridines having analgesic activity

Details Novel tetrahydropyridines having analgesic activity Novel tetrahydropyridines having analgesic activity

1988-07-01

1990-05-22

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 514307, 514314, 544335, 546112, 546146, 546168, 546175, C07D40104, C07D41314, C07D41714, A61K 31435

Patent

active

049278320

ABSTRACT:
Novel enantiomeric and diasteroisomeric forms of tetrahydropyridines of the formula ##STR1## wherein n.sub.1 is 0 or 2, A is selected from the group consisting of --(CH.sub.2).sub.n2 -- and alkylene substituted with alkyl having a total of 2 to 8 carbon atoms and n.sub.2 is 0 to 5, Z is selected from the group consisting of phenyl, naphthyl, indenyl, heteromonocycle of 5 to 6 ring members and heterobicycle, each optionally substituted with at least one substituent and their non-toxic, pharmaceutically acceptable acid addition salts and quaternary ammonium salts having central analgesic properties as well as diuretic, anti-arrhythmic, anti-cerebral-ischemia and hypotensive properties.

REFERENCES:
patent: 3679686 (1972-07-01), Hermans et al.
patent: 4337341 (1982-06-01), Zimmerman
patent: 4677122 (1987-06-01), Horwell
patent: 4816465 (1989-03-01), Clemence et al.
Clemence et al., Chemical Abstracts, vol. 109, No. 22848d (1988).
Kawahara et al., Chemical Abstracts, vol. 95, No. 61963z (1981).

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