Novel taurine derivatives

Details Novel taurine derivatives Novel taurine derivatives

1980-02-11

1981-03-31

Randolph, John D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

424266, 424308, 424309, 546318, 560 64, 560 66, A61K 3124, A61K 31325, A61K 31455, C07C 6986

Patent

active

042593328

ABSTRACT:
Novel taurine derivatives of general formula (I) ##STR1## (wherein R.sup.1 is nicotinoyl, 3,4,5-trimethoxybenzoyl or acetylsalicyloyl and R.sup.2 is as defined for R.sup.1 or is --CH.sub.2 CH.sub.2 OR.sup.1) have antilipemic and choleretic activities. The compound in which R.sup.2 .dbd.--CH.sub.2 CH.sub.2 OR.sup.1 and R.sup.1 is acetylsalicyloyl exhibits high antiinflammatory, analgesic and antipyretic activity and is essentially free of the unfavorable effect of acetylsalicylic acid on the stomach.

REFERENCES:
Derwent Belgian Patents Report 95B, Section 5 General Organic, p. 6, Feb. 1, 1963, (Abst. of Belgian Pat. No. 617,781).
Seventh Collective Index, vols. 56-65, p. 22,285S, American Chemical Society, copyrighted 1970, (under Taurine-).
Goldberg et al., Chem. Abstracts, vol. 40, col. 4436.sup.8 (1946).
Goldberg et al., Chem. Abstracts, vol. 41, col. 6900.sup.e (1947), (abst. of Brit. Pat. 586,453).
Distler et al., Chem. Abstracts, vol. 59. col. 511.sup.d (19), (abst. of Belg. Pat. No. 617,781, not available).
Seperic, Chem. Abstracts, vol. 82, abst. 64490k, (1975), (abst. of Ger. Offen. 2,406,366).

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