Novel synthetic undecapeptide and clinical assay

Details Novel synthetic undecapeptide and clinical assay Novel synthetic undecapeptide and clinical assay

1976-12-09

1978-02-21

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424 12, 424 88, C07C10352, A61K 3900

Patent

active

040751945

ABSTRACT:
A novel synthetic peptide corresponding to the eleven amino acid residues of the NH.sub.2 -terminal portion in the sequence of carcinoembrionic antigen (CEA) has been synthesized and this was attached by means of a water-soluble carbodiimide reagent to multichain poly(DL)-alanine as well as to bovine serum albumin. The resulting macromolecular conjugates provoked rabbit anti- CEA(1-11) peptide antibodies and a novel assay was developed for ascertaining the presence of adenocarcinomas of the digestive tract, pancreas and breast, based on said novel compositions of matter.

REFERENCES:
R. Aron, et al., Chem. Abst. 85, 1976, p. 121543t.
A. M. Reuter, et al., Chem. Abst. 86, 1977, p. 153709p.
T. S. Edgington, et al., Chem. Abst. 86, 1977, p. 153710g.

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