Novel synthetic peptide, process for its preparation and medicam

Details Novel synthetic peptide, process for its preparation and medicam Novel synthetic peptide, process for its preparation and medicam

1987-01-20

1990-02-06

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435810, 424 87, 530387, G01N 33569, A61K 3940

Patent

active

048988154

ABSTRACT:
The invention provides a synthetic peptide which reproduces at least 5 of the 11 amino acids common to the .gamma. chain of sub-unit A of cholera toxin and the .gamma. chain of LT toxin of Escherichia coli. It is preferably constituted by a pentadecapeptide which corresponds to the following formula (I): ##STR1## The process of synthesis is by the step by step construction of the peptide chain starting from the C terminal end of said chain, by the successive fixing of the amino acids which constitute the latter. A novel medicament for the treatment of cholera and infectious gastro-enterites comprises said synthetic peptide as active constituent. A diagnosis agent for cholera and/or infectious gastro-enterites comprises a sequence of nucleotides corresponding to the 5 minimum amino acids of the synthetic peptide.

REFERENCES:
patent: 4499080 (1985-02-01), Duflot et al.
Spicer et al, J. Biol. Chem., 257(10): 5716-5721, "Escherichia coli Heat Labile Enterotoxin", (1982, May).
Spicer et al, Proc. Nat'l. Acad. Sci. USA, 78(1): 50-54, "Sequence Homologies between A Subunits of Escherichia coli and Vibrio cholerae Enterotoxins", (1981).
Lindholm et al, Inf. Immun., 40(2): 570-576, "Monoclonal Antibodies to Cholera Toxin with Special Reference to Cross-Reactions with E. coli Heat Labile Enterotoxin", (May, 1983).
Robb et al, Inf. Immun., 38(1): 267-272, "Isolation of Hybridoma Cell Lines and Characterization of Monoclonal Antibodies Against Cholera Exterotoxin and its Subunits", (1982).
Clements et al., Inf. Immun., 21(3): 1036-1039, "Immunological Cross-Reactivity between a Heat-Labile Enterotoxin(s) of E. coli and Subunits of V. Choleare Enterotoxin", (1978).

Affiliated with

Also associated with

Rating

Novel synthetic peptide, process for its preparation and medicam does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Novel synthetic peptide, process for its preparation and medicam, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Novel synthetic peptide, process for its preparation and medicam will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-441570